Type 1 diabetes mellitus is believed to result from destruction of the insulin-producing β-cells
in pancreatic islets that is mediated by autoimmune mechanisms. The classic view is that …

Type 1 diabetes is an autoimmune disease caused by the immune-mediated destruction of
pancreatic β cells that results in lifelong absolute insulin deficiency. For nearly a century …

The clinical diagnosis of new-onset type 1 diabetes has, for many years, been considered
relatively straightforward. Recently, however, there is increasing awareness that within this …

Intraportal islet transplantation has proven to be efficacious in preventing severe
hypoglycemia and restoring insulin independence in selected patients with type 1 diabetes …

With the conceptual advance about four decades ago that type 1 diabetes represents an
autoimmune disease, hope arose that immune-based therapies would soon emerge to …

Type 1 Diabetes (T1D) is one of the most common chronic autoimmune diseases in children.
The disease is characterized by the destruction of beta cells, leading to hyperglycemia, and …

Hematopoietic stem cell (HSC) therapy is widely used to treat a growing number of
hematological and non-hematological diseases. Cryopreservation of HSCs allows for cells …

To evaluate the immunological mechanisms associated with clinical outcomes after
autologous hematopoietic stem cell transplantation (AHSCT), focusing on regulatory T …

Type 1 diabetes (T1D) remains a devastating disease that requires much effort to control.
Life-long daily insulin injections or an insulin pump are required to avoid severe …

Multiple sclerosis (MS) is an inflammatory disorder of the central nervous system where
evidence implicates an aberrant adaptive immune response in the accrual of neurological …