The emerging therapeutic potential of histone methyltransferase and demethylase inhibitors
A Spannhoff, AT Hauser, R Heinke… - ChemMedChem …, 2009 - Wiley Online Library
Epigenetics is defined as heritable changes to the transcriptome that are independent of
changes in the genome. The biochemical modifications that govern epigenetics are DNA …
changes in the genome. The biochemical modifications that govern epigenetics are DNA …
The role of genetic markers in the management of prostate cancer
CONTEXT: Despite widespread screening for prostate cancer (PCa) and major advances in
the treatment of metastatic disease, PCa remains the second most common cause of cancer …
the treatment of metastatic disease, PCa remains the second most common cause of cancer …
From transcriptome analysis to therapeutic anti-CD40L treatment in the SOD1 model of amyotrophic lateral sclerosis
JM Lincecum, FG Vieira, MZ Wang, K Thompson… - Nature …, 2010 - nature.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
progressive loss of motor neurons. Using unbiased transcript profiling in an ALS mouse …
progressive loss of motor neurons. Using unbiased transcript profiling in an ALS mouse …
[HTML][HTML] Microarray data quality control improves the detection of differentially expressed genes
A Kauffmann, W Huber - Genomics, 2010 - Elsevier
Microarrays have become a routine tool for biomedical research. Data quality assessment is
an essential part of the analysis, but it is still not easy to perform objectively or in an …
an essential part of the analysis, but it is still not easy to perform objectively or in an …
miR-1 and miR-133b are differentially expressed in patients with recurrent prostate cancer
Prostate cancer (PCa) is currently the most frequently diagnosed malignancy in the western
countries. It is more prevalent in older men with 75% of the incident cases above 65 years …
countries. It is more prevalent in older men with 75% of the incident cases above 65 years …
MicroRNA-100 expression is independently related to biochemical recurrence of prostate cancer
PURPOSE:: Abnormal miRNA expression has emerged as crucial factors in carcinogenesis
and is important in the comprehension of prostate cancer behavior. We determined the …
and is important in the comprehension of prostate cancer behavior. We determined the …
Cancer treatment of the future: inhibitors of histone methyltransferases
Cancer in humans is the result of a multi-step process. This process often involves the
activation of oncogenes and/or the inactivation of tumor suppressor genes. These two steps …
activation of oncogenes and/or the inactivation of tumor suppressor genes. These two steps …
Differential expression of apoptotic genes PDIA3 and MAP3K5 distinguishes between low- and high-risk prostate cancer
NC Pressinotti, H Klocker, G Schäfer, VD Luu… - Molecular cancer, 2009 - Springer
Background Despite recent progress in the identification of genetic and molecular
alterations in prostate cancer, markers associated with tumor progression are scarce …
alterations in prostate cancer, markers associated with tumor progression are scarce …
MicroRNAs as prognostic markers in prostate cancer
Background Prostate cancer (PCa) is the most commonly diagnosed malignancy in men
who are especially over the age of 50 years in the western countries. Currently used …
who are especially over the age of 50 years in the western countries. Currently used …
Regulatory BCL2 promoter polymorphism (−938C>A) is associated with adverse outcome in patients with prostate carcinoma
HS Bachmann, LC Heukamp… - … journal of cancer, 2011 - Wiley Online Library
Molecular markers predictive of prostate cancer prognosis are urgently needed.
Overexpression of the antiapoptotic protein, Bcl‐2, has repeatedly been shown to be …
Overexpression of the antiapoptotic protein, Bcl‐2, has repeatedly been shown to be …