Highlights•Multiple immune evasion strategies support B. burgdorferi (Bb) persistent
infection.•CD4 Th1 polarization correlates with Bb-induced disease not protection.•Neither …

Mechanisms that regulate metabolites and downstream energy generation are key
determinants of T cell cytokine production, but the processes underlying the Th17 profile that …

Interferon Regulatory Factor 5 (IRF5) is one of nine members of the IRF family of
transcription factors. Although initially discovered as a key regulator of the type I interferon …

RBC transfusion therapy is essential for the treatment of anemia. A serious complication of
transfusion is the development of non-ABO alloantibodies to polymorphic RBC Ags; yet …

Myeloid differentiation primary response protein-88 (MYD88) is an essential adaptor
molecule in pathogen-related pattern recognition signaling pathways. Toll-like and …

IL-1β plays critical roles in the priming and effector phases of immune responses such as the
differentiation, commitment, and memory formation of T cells. In this context, several reports …

摘要近年来, 免疫机制特别是T 淋巴细胞参与的免疫反应在高血压肾损伤中备受关注.
高血压期间新抗原产生, 共刺激信号, 交感神经兴奋和高浓度盐可激活T 淋巴细胞, 被激活的T …

Dengue virus (DENV) has been considered a worldwide health threat since up to 350
million individuals live in high-risk transmission areas. The rate of Dengue infection has …

The gut is the largest lymphoid organ in the body. Due to intense and constant exposure to
the outside world, it also functions as the most important portal of entry for many pathogens …