EMT transition states during tumor progression and metastasis

I Pastushenko, C Blanpain - Trends in cell biology, 2019 - cell.com
Epithelial–mesenchymal transition (EMT) is a process in which epithelial cells acquire
mesenchymal features. In cancer, EMT is associated with tumor initiation, invasion …

The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation

J Haerinck, S Goossens, G Berx - Nature Reviews Genetics, 2023 - nature.com
Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …

Controversies around epithelial–mesenchymal plasticity in cancer metastasis

ED Williams, D Gao, A Redfern… - Nature Reviews Cancer, 2019 - nature.com
Experimental evidence accumulated over decades has implicated epithelial–mesenchymal
plasticity (EMP), which collectively encompasses epithelial–mesenchymal transition and the …

IgA nephropathy

E Stamellou, C Seikrit, SCW Tang, P Boor… - Nature Reviews …, 2023 - nature.com
IgA nephropathy (IgAN), the most prevalent primary glomerulonephritis worldwide, carries a
considerable lifetime risk of kidney failure. Clinical manifestations of IgAN vary from …

Implications of the hybrid epithelial/mesenchymal phenotype in metastasis

MK Jolly, M Boareto, B Huang, D Jia, M Lu… - Frontiers in …, 2015 - frontiersin.org
Transitions between epithelial and mesenchymal phenotypes–the epithelial to
mesenchymal transition (EMT) and its reverse the mesenchymal to epithelial transition …

Hybrid epithelial/mesenchymal phenotypes promote metastasis and therapy resistance across carcinomas

MK Jolly, JA Somarelli, M Sheth, A Biddle… - Pharmacology & …, 2019 - Elsevier
Cancer metastasis and therapy resistance are the major unsolved clinical challenges, and
account for nearly all cancer-related deaths. Both metastasis and therapy resistance are …

EMT and MET: necessary or permissive for metastasis?

MK Jolly, KE Ware, S Gilja, JA Somarelli… - Molecular …, 2017 - Wiley Online Library
Epithelial‐to‐mesenchymal transition (EMT) and its reverse mesenchymal‐to‐epithelial
transition (MET) have been suggested to play crucial roles in metastatic dissemination of …

[HTML][HTML] Stability of the hybrid epithelial/mesenchymal phenotype

MK Jolly, SC Tripathi, D Jia, SM Mooney, M Celiktas… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Abstract Epithelial-to-Mesenchymal Transition (EMT) and its reverse–Mesenchymal to
Epithelial Transition (MET)–are hallmarks of cellular plasticity during embryonic …

EMT: Present and future in clinical oncology

PG Santamaria, G Moreno‐Bueno, F Portillo… - Molecular …, 2017 - Wiley Online Library
Epithelial/mesenchymal transition (EMT) has emerged as a key regulator of metastasis by
facilitating tumor cell invasion and dissemination to distant organs. Recent evidences …

[HTML][HTML] Hypoxia, partial EMT and collective migration: Emerging culprits in metastasis

K Saxena, MK Jolly, K Balamurugan - Translational oncology, 2020 - Elsevier
Epithelial-mesenchymal transition (EMT) is a cellular biological process involved in
migration of primary cancer cells to secondary sites facilitating metastasis. Besides, EMT …