NANOBODY®(a registered trademark of Ablynx NV) molecules (Nbs), also referred to as
single domain-based VHHs, are antibody fragments derived from heavy-chain only IgG …

Unique, functional, homodimeric heavy chain–only antibodies, devoid of light chains, are
circulating in the blood of Camelidae. These antibodies recognize their cognate antigen via …

A nanobody (Nb) is a registered trademark of Ablynx, referring to the single antigen‐binding
domain of heavy chain‐only antibodies (HCAbs) that are circulating in Camelidae. Nbs are …

Camelid single-domain antibody fragments ('nanobodies') provide the remarkable specificity
of antibodies within a single 15-kDa immunoglobulin VHH domain. This unique feature has …

Abstract SARS-CoV-2, the causative agent of COVID-19, features a receptor-binding domain
(RBD) for binding to the host cell ACE2 protein,,,,–. Neutralizing antibodies that block RBD …

Since the start of the COVID-19 pandemic, SARS-CoV-2 has caused millions of deaths
worldwide. Although a number of vaccines have been deployed, the continual evolution of …

Mechanistic and structural studies of membrane proteins require their stabilization in specific
conformations. Single domain antibodies are potent reagents for this purpose, but their …

Monoclonal antibodies have emerged as key therapeutics. In particular, nanobodies, small,
single-domain antibodies that are naturally expressed in camelids, are rapidly gaining …

The unique class of heavy chain–only antibodies, present in Camelidae, can be shrunk to
just the variable region of the heavy chain to yield VHHs, also called nanobodies. About one …

Single‐domain antibodies (sdAbs), the autonomous variable domains of camelid and shark
heavy‐chain antibodies, have many desirable properties as components of biologic drugs …