Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …

Induced pluripotent stem cell (iPSC)-based disease modelling and the cell replacement
therapy approach have proven to be very powerful and instrumental in biomedical research …

Cardiovascular diseases are the leading cause of death worldwide. Therefore, the discovery
of induced pluripotent stem cells (iPSCs) and the subsequent generation of human induced …

Rationale: Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) are a readily
available, robustly reproducible, and physiologically appropriate human cell source for …

Pluripotent stem-cell-derived cardiomyocytes (PSC-CMs) provide an unprecedented
opportunity to study human heart development and disease, but they are functionally and …

The adult heart is a vital and highly specialized organ of the human body, with limited
capability of self-repair and regeneration in case of injury or disease. Engineering …

Currently, due to the increasing demand for 3D culture, various organoids that mimic organs
are being actively studied. Despite active reports, information on heart organoids (HOs) …

Three-dimensional (3D) cell culture is often mentioned in the context of regenerative
medicine, for example, for the replacement of ischemic myocardium with tissue-engineered …

Abstract Development of new drugs is of high interest for the field of cardiac and
cardiovascular diseases, which are a dominant cause of death worldwide. Before being …

Induced pluripotent stem cells (iPSCs) were first generated by Yamanaka and colleagues
over a decade ago. Since then, iPSCs have been successfully differentiated into many …