After advanced age, female sex is the major risk factor for late-onset Alzheimer's disease
(AD), the most common cause of dementia affecting over 24 million people worldwide. The …

Despite widespread sex differences in prevalence and presentation of numerous illnesses
affecting the human brain, there has been little focus on the effect of endocrine ageing. Most …

Introduction Despite a large preclinical literature demonstrating neuroprotective effects of
estrogen, use of menopausal hormone therapy (HT) for Alzheimer's disease (AD) risk …

Ovarian hormones, particularly 17β-estradiol, are involved in numerous neurophysiological
and neurochemical processes, including those subserving cognitive function. Estradiol plays …

The temporal characteristics of adolescent neurodevelopment are shaped by a complex
interplay of genetic, biological, and environmental factors. Using a large longitudinal dataset …

Background and Objectives The menopause transition is increasingly recognized as a time
of importance for women's brain health. A growing body of work indicates that the classic …

Alzheimer's disease (AD) is characterized by numerous sexual dimorphisms that impact the
development, progression, and probably the strategies to prevent and treat the most …

Increasing evidence implicates sex and endocrine aging effects on brain bioenergetic aging
in the greater lifetime risk of Alzheimer's disease (AD) in women. We conducted …

Introduction This increasing body of literature indicates that menopause hormonal
replacement therapy (MHT) may substantially mitigate the risk of developing late‐life …

Age, female sex, and APOE epsilon 4 (APOE4) genotype are the three greatest risk factors
for late-onset Alzheimer's disease (AD). The convergence of these risks creates a …