A review of optimization and quantification techniques for chemical exchange saturation transfer MRI toward sensitive in vivo imaging
J Kim, Y Wu, Y Guo, H Zheng… - Contrast media & …, 2015 - Wiley Online Library
Chemical exchange saturation transfer (CEST) MRI is a versatile imaging method that
probes the chemical exchange between bulk water and exchangeable protons. CEST …
probes the chemical exchange between bulk water and exchangeable protons. CEST …
Non-invasive investigation of tumor metabolism and acidosis by MRI-CEST imaging
Altered metabolism is considered a core hallmark of cancer. By monitoring in vivo
metabolites changes or characterizing the tumor microenvironment, non-invasive imaging …
metabolites changes or characterizing the tumor microenvironment, non-invasive imaging …
Relaxation-compensated CEST-MRI of the human brain at 7 T: unbiased insight into NOE and amide signal changes in human glioblastoma
Endogenous chemical exchange saturation transfer (CEST) effects of protons resonating
near to water protons are always diluted by competing effects such as direct water saturation …
near to water protons are always diluted by competing effects such as direct water saturation …
In Vivo Imaging of Tumor Metabolism and Acidosis by Combining PET and MRI-CEST pH Imaging
DL Longo, A Bartoli, L Consolino, P Bardini, F Arena… - Cancer research, 2016 - AACR
The vast majority of cancers exhibit increased glucose uptake and glycolysis regardless of
oxygen availability. This metabolic shift leads to an enhanced production of lactic acid that …
oxygen availability. This metabolic shift leads to an enhanced production of lactic acid that …
A General MRI-CEST Ratiometric Approach for pH Imaging: Demonstration of in Vivo pH Mapping with Iobitridol
Chemical exchange saturation transfer (CEST) is a novel contrast mechanism for magnetic
resonance imaging (MRI). CEST MRI selectively saturates exchangeable protons that are …
resonance imaging (MRI). CEST MRI selectively saturates exchangeable protons that are …
Downfield‐NOE‐suppressed amide‐CEST‐MRI at 7 Tesla provides a unique contrast in human glioblastoma
Purpose The chemical exchange saturation transfer (CEST) effect observed in brain tissue
in vivo at the frequency offset 3.5 ppm downfield of water was assigned to amide protons of …
in vivo at the frequency offset 3.5 ppm downfield of water was assigned to amide protons of …
Relaxation-compensated amide proton transfer (APT) MRI signal intensity is associated with survival and progression in high-grade glioma patients
D Paech, C Dreher, S Regnery, JE Meissner… - European …, 2019 - Springer
Objectives The purpose of this study was to investigate the association of relaxation-
compensated chemical exchange saturation transfer (CEST) MRI with overall survival (OS) …
compensated chemical exchange saturation transfer (CEST) MRI with overall survival (OS) …
Signature of protein unfolding in chemical exchange saturation transfer imaging
Chemical exchange saturation transfer (CEST) allows the detection of metabolites of low
concentration in tissue with nearly the sensitivity of MRI with water protons. With this …
concentration in tissue with nearly the sensitivity of MRI with water protons. With this …
Molecular imaging of brain tumors and drug delivery using CEST MRI: promises and challenges
Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) detects
molecules in their natural forms in a sensitive and non-invasive manner. This makes it a …
molecules in their natural forms in a sensitive and non-invasive manner. This makes it a …
Mapping intracellular pH in tumors using amide and guanidyl CEST‐MRI at 9.4 T
PS Boyd, J Breitling, A Korzowski… - Magnetic …, 2022 - Wiley Online Library
Purpose In principle, non‐invasive mapping of the intracellular pH (pHi) in vivo is possible
using endogenous chemical exchange saturation transfer (CEST)‐MRI of the amide and …
using endogenous chemical exchange saturation transfer (CEST)‐MRI of the amide and …