Alzheimer's disease (AD) is characterized by specific alterations of brain DNA methylation
(DNAm) patterns. Age and sex, two major risk factors for AD, are also known to largely affect …

Introduction: Most medical diagnoses present somewhat differently in men and women,
more so at specific periods of life. Treatment effects may also differ. This is true for …

Many psychiatric disorders exhibit sex differences, but the underlying mechanisms remain
poorly understood. We analyzed transcriptomics data from 2160 postmortem adult prefrontal …

Background Sex differences are known to play a role in disease aetiology, progression and
outcome. Previous studies have revealed autosomal epigenetic differences between males …

Neurological and neuropsychiatric disorders affect men and women differently. Multiple
sclerosis, Alzheimer's disease, anxiety disorders, depression, meningiomas and late-onset …

Sex presents a vital determinant of a person's physiology, anatomy, and development.
Recent clinical studies indicate that sex is also involved in the differential manifestation of …

Many neuropsychiatric disorders exhibit differences in prevalence, age of onset, symptoms
or course of illness between males and females. For the most part, the origins of these …

Although male–female differences in placental structure and function have been observed,
little is understood about their molecular underpinnings. Here, we present a mega-analysis …

Sex is an important factor that contributes to the clinical and biological heterogeneities in
Alzheimer's disease (AD), but the regulatory mechanisms underlying sex disparity in AD are …

Pharmacotherapy is the most common treatment for schizophrenia (SCZ), bipolar disorder
(BD), and major depressive disorder (MDD). Pharmacogenetic studies have achieved …