[HTML][HTML] Oligodendrocyte dysfunction in amyotrophic lateral sclerosis: mechanisms and therapeutic perspectives
S Raffaele, M Boccazzi, M Fumagalli - Cells, 2021 - mdpi.com
Myelin is the lipid-rich structure formed by oligodendrocytes (OLs) that wraps the axons in
multilayered sheaths, assuring protection, efficient saltatory signal conduction and metabolic …
multilayered sheaths, assuring protection, efficient saltatory signal conduction and metabolic …
Presymptomatic spinal cord pathology in c9orf72 mutation carriers: A longitudinal neuroimaging study
Objective C9orf72 hexanucleotide repeats expansions account for almost half of familial
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) cases. Recent …
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) cases. Recent …
Diffusion tensor imaging in preclinical and human studies of huntington's disease: what have we learned so far?
RG Gatto, C Weissmann - Current Medical Imaging, 2019 - ingentaconnect.com
Background: Huntington's Disease is an irreversible neurodegenerative disease
characterized by the progressive deterioration of specific brain nerve cells. The current …
characterized by the progressive deterioration of specific brain nerve cells. The current …
[HTML][HTML] GPX4 deficiency-dependent phospholipid peroxidation drives motor deficits of ALS
LF Tu, TZ Zhang, YF Zhou, QQ Zhou, HB Gong… - Journal of Advanced …, 2023 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease
characterized by oxidative stress that triggers motor neurons loss in the brain and spinal …
characterized by oxidative stress that triggers motor neurons loss in the brain and spinal …
Detection of axonal degeneration in a mouse model of Huntington's disease: comparison between diffusion tensor imaging and anomalous diffusion metrics
Objective The goal of this work is to study the changes in white matter integrity in R6/2, a
well-established animal model of Huntington's disease (HD) that are captured by ex vivo …
well-established animal model of Huntington's disease (HD) that are captured by ex vivo …
[HTML][HTML] Neurite orientation dispersion and density imaging can detect presymptomatic axonal degeneration in the spinal cord of ALS mice
Neurite orientation dispersion and density imaging (NODDI), a MRI multi-shell diffusion
technique, has offered new insights for the study of microstructural changes in …
technique, has offered new insights for the study of microstructural changes in …
[HTML][HTML] Ultra-high field diffusion MRI reveals early axonal pathology in spinal cord of ALS mice
Background Amyotrophic lateral sclerosis (ALS) is a disease characterized by a progressive
degeneration of motor neurons leading to paralysis. Our previous MRI diffusion tensor …
degeneration of motor neurons leading to paralysis. Our previous MRI diffusion tensor …
[HTML][HTML] VGF nerve growth factor inducible is involved in retinal ganglion cells death induced by optic nerve crush
H Takeuchi, S Inagaki, W Morozumi, Y Nakano… - Scientific Reports, 2018 - nature.com
VGF nerve growth factor inducible (VGF) is a polypeptide that is induced by neurotrophic
factors and is involved in neurite growth and neuroprotection. The mRNA of the Vgf gene …
factors and is involved in neurite growth and neuroprotection. The mRNA of the Vgf gene …
[HTML][HTML] Brain magnetic resonance imaging characteristics of anti-leucine-rich glioma-inactivated 1 encephalitis and their clinical relevance: a single-center study in …
X Shao, S Fan, H Luo, TY Wong, W Zhang… - Frontiers in …, 2021 - frontiersin.org
Objective: To characterize the magnetic resonance imaging (MRI) features of anti-leucine-
rich glioma-inactivated 1 (LGI1) encephalitis and explore their clinical relevance. Methods …
rich glioma-inactivated 1 (LGI1) encephalitis and explore their clinical relevance. Methods …
Identifying potential imaging markers for diffusion property changes in a mouse model of amyotrophic lateral sclerosis: Application of the continuous time random walk …
Diffusion MRI (dMRI) explores tissue microstructures by analyzing diffusion‐weighted signal
decay measured at different b‐values. While relatively low b‐values are used for most dMRI …
decay measured at different b‐values. While relatively low b‐values are used for most dMRI …