Inositol Trisphosphate Receptor Ca2+ Release Channels
The inositol 1, 4, 5-trisphosphate (InsP3) receptors (InsP3Rs) are a family of Ca2+ release
channels localized predominately in the endoplasmic reticulum of all cell types. They …
channels localized predominately in the endoplasmic reticulum of all cell types. They …
Structure and function of IP3 receptors
Inositol 1, 4, 5-trisphosphate receptors (IP3Rs), by releasing Ca2+ from the endoplasmic
reticulum (ER) of animal cells, allow Ca2+ to be redistributed from the ER to the cytosol or …
reticulum (ER) of animal cells, allow Ca2+ to be redistributed from the ER to the cytosol or …
[HTML][HTML] Ca2+ transfer from the ER to mitochondria: when, how and why
The heterogenous subcellular distribution of a wide array of channels, pumps and
exchangers allows extracellular stimuli to induce increases in cytoplasmic Ca2+ …
exchangers allows extracellular stimuli to induce increases in cytoplasmic Ca2+ …
IP3 receptor/Ca2+ channel: from discovery to new signaling concepts
K Mikoshiba - Journal of neurochemistry, 2007 - Wiley Online Library
Abstract Inositol 1, 4, 5‐trisphosphate (IP3) is a second messenger that induces the release
of Ca2+ from the endoplasmic reticulum (ER). The IP3 receptor (IP3R) was discovered as a …
of Ca2+ from the endoplasmic reticulum (ER). The IP3 receptor (IP3R) was discovered as a …
Ca2+ signals initiate at immobile IP3 receptors adjacent to ER-plasma membrane junctions
NB Thillaiappan, AP Chavda, SC Tovey… - Nature …, 2017 - nature.com
Abstract IP3 receptors (IP3Rs) release Ca2+ from the ER when they bind IP3 and Ca2+. The
spatial organization of IP3Rs determines both the propagation of Ca2+ signals between …
spatial organization of IP3Rs determines both the propagation of Ca2+ signals between …
Defining the stoichiometry of inositol 1,4,5-trisphosphate binding required to initiate Ca2+ release
KJ Alzayady, L Wang, R Chandrasekhar… - Science …, 2016 - science.org
Inositol 1, 4, 5-trisphosphate (IP3) receptors (IP3Rs) are tetrameric intracellular Ca2+-
release channels with each subunit containing a binding site for IP3 in the amino terminus …
release channels with each subunit containing a binding site for IP3 in the amino terminus …
Physiology and pathology of calcium signaling in the brain
Calcium (Ca2+) plays fundamental and diversified roles in neuronal plasticity. As second
messenger of many signaling pathways, Ca2+ as been shown to regulate neuronal gene …
messenger of many signaling pathways, Ca2+ as been shown to regulate neuronal gene …
[HTML][HTML] Inositol 1, 4, 5-trisphosphate receptor-isoform diversity in cell death and survival
H Ivanova, T Vervliet, L Missiaen, JB Parys… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Cell-death and-survival decisions are critically controlled by intracellular Ca 2+ homeostasis
and dynamics at the level of the endoplasmic reticulum (ER). Inositol 1, 4, 5-trisphosphate …
and dynamics at the level of the endoplasmic reticulum (ER). Inositol 1, 4, 5-trisphosphate …
Role of IP3 receptor signaling in cell functions and diseases
K Mikoshiba - Advances in biological regulation, 2015 - Elsevier
Abstract IP 3 receptor (IP 3 R) was found to release Ca 2+ from non-mitochondrial store but
the exact localization and the mode of action of IP 3 remained a mystery. IP 3 R was …
the exact localization and the mode of action of IP 3 remained a mystery. IP 3 R was …
Genetic polymorphism and protein conformational plasticity in the calmodulin superfamily: two ways to promote multifunctionality
M Ikura, JB Ames - Proceedings of the National Academy of …, 2006 - National Acad Sciences
Calcium signaling pathways control a variety of cellular events such as gene transcription,
protein phosphorylation, nucleotide metabolism, and ion transport. These pathways often …
protein phosphorylation, nucleotide metabolism, and ion transport. These pathways often …