Mechanisms and consequences of sex differences in immune responses

SE Dunn, WA Perry, SL Klein - Nature Reviews Nephrology, 2024 - nature.com
Biological sex differences refer to differences between males and females caused by the sex
chromosome complement (that is, XY or XX), reproductive tissues (that is, the presence of …

Sex—the most underappreciated variable in research: insights from helminth-infected hosts

A Wesołowska - Veterinary Research, 2022 - Springer
The sex of a host affects the intensity, prevalence, and severity of helminth infection. In many
cases, one sex has been found to be more susceptible than the other, with the prevalence …

Sex-based differences in clearance of chronic Plasmodium falciparum infection

J Briggs, N Teyssier, JI Nankabirwa, J Rek… - Elife, 2020 - elifesciences.org
Multiple studies have reported a male bias in incidence and/or prevalence of malaria
infection in males compared to females. To test the hypothesis that sex-based differences in …

[HTML][HTML] NK cells associate with ALS in a sex-and age-dependent manner

BJ Murdock, JP Famie, CE Piecuch, KD Pawlowski… - JCI insight, 2021 - ncbi.nlm.nih.gov
NK cells are innate immune cells implicated in ALS; whether NK cells impact ALS in a sex-
and age-specific manner was investigated. Herein, NK cells were depleted in male and …

Malaria infection among adults residing in a highly endemic region from the Democratic Republic of the Congo

NK Kayiba, Y Nitahara, E Tshibangu-Kabamba… - Malaria Journal, 2024 - Springer
Abstract Background Adults infected with Plasmodium spp. in endemic areas need to be re-
evaluated in light of global malaria elimination goals. They potentially undermine malaria …

Greater breadth of vaccine-induced immunity in females than males is mediated by increased antibody diversity in germinal center B cells

RL Ursin, S Dhakal, H Liu, S Jayaraman, HS Park… - MBio, 2022 - Am Soc Microbiol
Inactivated influenza vaccines induce greater antibody responses in females than males
among both humans and mice. To test the breadth of protection, we used recombinant …

Estradiol mediates greater germinal center responses to influenza vaccination in female than male mice

S Dhakal, HS Park, K Seddu, JS Lee, PS Creisher… - Mbio, 2024 - Am Soc Microbiol
Adult females of reproductive age develop greater antibody responses to inactivated
influenza vaccines (IIV) than males. How sex, age, and sex steroid concentrations impact B …

Needle-free, spirulina-produced Plasmodium falciparum circumsporozoite vaccination provides sterile protection against pre-erythrocytic malaria in mice

T Saveria, C Parthiban, AM Seilie, C Brady, A Martinez… - npj Vaccines, 2022 - nature.com
Antibodies against the Plasmodium falciparum circumsporozoite protein (PfCSP) can block
hepatocyte infection by sporozoites and protect against malaria. Needle-free vaccination …

Estrogen, the Peripheral Immune System and Major Depression–A Reproductive Lifespan Perspective

EB Engler-Chiurazzi, WH Chastain… - Frontiers in Behavioral …, 2022 - frontiersin.org
Major depression is a significant medical issue impacting millions of individuals worldwide.
Identifying factors contributing to its manifestation has been a subject of intense investigation …

The effect of chronic stress on the immunogenicity and immunoprotection of the M6-TT vaccine in female mice

SB Méndez, M Matus-Ortega, RH Miramontes… - Physiology & …, 2023 - Elsevier
Active vaccination is an effective therapeutic option to reduce the reinforcing effects of
opioids. Several studies showed that chronic stress affects the immune system decreasing …