Current developments of coumarin compounds in medicinal chemistry
XM Peng, G LV Damu, H Zhou - Current pharmaceutical …, 2013 - ingentaconnect.com
Coumarin compounds represent an important type of naturally occurring and synthetic
oxygen-containing heterocycles with typical benzopyrone framework. This type of special …
oxygen-containing heterocycles with typical benzopyrone framework. This type of special …
A review of the mechanisms and effectiveness of dietary polyphenols in reducing oxidative stress and thrombotic risk
AB Santhakumar, AC Bulmer… - Journal of Human …, 2014 - Wiley Online Library
Dietary sources of polyphenols, which are derivatives and/or isomers of flavones,
isoflavones, flavonols, catechins and phenolic acids, possess antioxidant properties and …
isoflavones, flavonols, catechins and phenolic acids, possess antioxidant properties and …
The antithrombotic activity of natural and synthetic coumarins
Thrombosis, which seriously endangers human health and life, is the leading cause of
morbidity and mortality globally. Antithrombotic drugs can interfere with the occurrence and …
morbidity and mortality globally. Antithrombotic drugs can interfere with the occurrence and …
[HTML][HTML] Synthetic coumarin derivatives with anticoagulation and antiplatelet aggregation inhibitory effects
Thrombosis is the leading cause of illness and mortality worldwide, posing a serious risk to
human health and life. Because antithrombotic drugs can prevent the beginning and …
human health and life. Because antithrombotic drugs can prevent the beginning and …
Coumarins scaffolds as COX inhibitors
The discovery of COX enzymes has led to a better understanding of inflammation and its
related biological pathways. Apart from being related to inflammation and pain, it has also …
related biological pathways. Apart from being related to inflammation and pain, it has also …
[HTML][HTML] Developing multitarget coumarin based anti-breast cancer agents: synthesis and molecular modeling study
A new series of 7-substituted coumarin scaffolds containing a methyl ester moiety at the C4-
position were synthesized and tested for their in vitro anti-proliferative activity against MCF-7 …
position were synthesized and tested for their in vitro anti-proliferative activity against MCF-7 …
Multifunctional coumarin derivatives: monoamine oxidase B (MAO-B) inhibition, anti-β-amyloid (Aβ) aggregation and metal chelation properties against Alzheimer's …
M Huang, SS Xie, N Jiang, JS Lan, LY Kong… - Bioorganic & medicinal …, 2015 - Elsevier
A series of coumarin derivatives were designed, synthesized, and evaluated as novel
multifunctional agents against Alzheimer's disease (AD). In vitro studies showed that most of …
multifunctional agents against Alzheimer's disease (AD). In vitro studies showed that most of …
Design, synthesis and antifungal activities of novel pyrrole-and pyrazole-substituted coumarin derivatives
SG Zhang, CG Liang, YQ Sun, P Teng, JQ Wang… - Molecular Diversity, 2019 - Springer
We synthesized a series of novel pyrrole-and pyrazole-substituted coumarin derivatives and
evaluated their antifungal activity against six phytopathogenic fungi in vitro. The primary …
evaluated their antifungal activity against six phytopathogenic fungi in vitro. The primary …
[HTML][HTML] Novel coumarin 7-carboxamide/sulfonamide derivatives as potential fungicidal agents: design, synthesis, and biological evaluation
SG Zhang, YQ Wan, Y Wen, WH Zhang - Molecules, 2022 - mdpi.com
Coumarin compounds have a variety of biological activities such as anti-tumor, anti-
coagulation, anti-HIV, anti-fungal, and insecticidal. Amide and sulfonamide compounds …
coagulation, anti-HIV, anti-fungal, and insecticidal. Amide and sulfonamide compounds …
Structure–activity relationship studies of 4-methylcoumarin derivatives as anticancer agents
Context: Cancer is a leading cause of death worldwide and novel chemotherapeutic agents
with better efficacy and safety profiles are much needed. Coumarins are natural …
with better efficacy and safety profiles are much needed. Coumarins are natural …