Current developments of coumarin compounds in medicinal chemistry

XM Peng, G LV Damu, H Zhou - Current pharmaceutical …, 2013 - ingentaconnect.com
Coumarin compounds represent an important type of naturally occurring and synthetic
oxygen-containing heterocycles with typical benzopyrone framework. This type of special …

A review of the mechanisms and effectiveness of dietary polyphenols in reducing oxidative stress and thrombotic risk

AB Santhakumar, AC Bulmer… - Journal of Human …, 2014 - Wiley Online Library
Dietary sources of polyphenols, which are derivatives and/or isomers of flavones,
isoflavones, flavonols, catechins and phenolic acids, possess antioxidant properties and …

The antithrombotic activity of natural and synthetic coumarins

L Gao, F Wang, Y Chen, F Li, B Han, D Liu - Fitoterapia, 2021 - Elsevier
Thrombosis, which seriously endangers human health and life, is the leading cause of
morbidity and mortality globally. Antithrombotic drugs can interfere with the occurrence and …

[HTML][HTML] Synthetic coumarin derivatives with anticoagulation and antiplatelet aggregation inhibitory effects

TM Ramsis, MA Ebrahim, EA Fayed - Medicinal Chemistry Research, 2023 - Springer
Thrombosis is the leading cause of illness and mortality worldwide, posing a serious risk to
human health and life. Because antithrombotic drugs can prevent the beginning and …

Coumarins scaffolds as COX inhibitors

HM Revankar, SNA Bukhari, GB Kumar, HL Qin - Bioorganic Chemistry, 2017 - Elsevier
The discovery of COX enzymes has led to a better understanding of inflammation and its
related biological pathways. Apart from being related to inflammation and pain, it has also …

[HTML][HTML] Developing multitarget coumarin based anti-breast cancer agents: synthesis and molecular modeling study

FN Takla, WA Bayoumi, SM El-Messery, MNA Nasr - Scientific Reports, 2023 - nature.com
A new series of 7-substituted coumarin scaffolds containing a methyl ester moiety at the C4-
position were synthesized and tested for their in vitro anti-proliferative activity against MCF-7 …

Multifunctional coumarin derivatives: monoamine oxidase B (MAO-B) inhibition, anti-β-amyloid (Aβ) aggregation and metal chelation properties against Alzheimer's …

M Huang, SS Xie, N Jiang, JS Lan, LY Kong… - Bioorganic & medicinal …, 2015 - Elsevier
A series of coumarin derivatives were designed, synthesized, and evaluated as novel
multifunctional agents against Alzheimer's disease (AD). In vitro studies showed that most of …

Design, synthesis and antifungal activities of novel pyrrole-and pyrazole-substituted coumarin derivatives

SG Zhang, CG Liang, YQ Sun, P Teng, JQ Wang… - Molecular Diversity, 2019 - Springer
We synthesized a series of novel pyrrole-and pyrazole-substituted coumarin derivatives and
evaluated their antifungal activity against six phytopathogenic fungi in vitro. The primary …

[HTML][HTML] Novel coumarin 7-carboxamide/sulfonamide derivatives as potential fungicidal agents: design, synthesis, and biological evaluation

SG Zhang, YQ Wan, Y Wen, WH Zhang - Molecules, 2022 - mdpi.com
Coumarin compounds have a variety of biological activities such as anti-tumor, anti-
coagulation, anti-HIV, anti-fungal, and insecticidal. Amide and sulfonamide compounds …

Structure–activity relationship studies of 4-methylcoumarin derivatives as anticancer agents

R Miri, M Nejati, L Saso, F Khakdan… - Pharmaceutical …, 2016 - Taylor & Francis
Context: Cancer is a leading cause of death worldwide and novel chemotherapeutic agents
with better efficacy and safety profiles are much needed. Coumarins are natural …