The elderly population is growing worldwide, with important health and socioeconomic
implications. Clinical and experimental studies on aging have uncovered numerous …

The current knowledge of the normal biochemistry of compounds that give rise to
resonances in human brain proton magnetic resonance spectra measureable at readily …

Background A proposed mechanism of chronic pain is dysregulation between the main
inhibitory (GABA) and excitatory (glutamate) neurometabolites of the central nervous system …

Glutamate is one of the most abundant of the amino acids. In addition to its role in protein
structure, it plays critical roles in nutrition, metabolism and signaling. Post-translational …

Alcohol consumption is an integral part of daily life in many societies. The benefits
associated with the production, sale, and use of alcoholic beverages come at an enormous …

The astrocytic glutamate transporters excitatory amino acid transporters 1 and 2 (EAAT1 and
EAAT2) play a key role in nervous system function to maintain extracellular glutamate levels …

Our understanding of the roles that the amino acids glutamate (Glu) and glutamine (Gln)
play in the mammalian central nervous system has increased rapidly in recent times. Many …

Objective Central pain augmentation resulting from enhanced excitatory and/or decreased
inhibitory neurotransmission is a proposed mechanism underlying the pathophysiology of …

Histopathological reports of multiple sclerosis and its animal models have shown evidence
of a link between axonal injury in active lesions and impaired glutamate metabolism. Mature …

The Proton magnetic resonance (1H‐MRS) spectrum contains information about the
concentration of tissue metabolites within a predefined region of interest (a voxel). The …