Breast cancer is a complex disease encompassing multiple tumor entities, each
characterized by distinct morphology, behavior and clinical implications. Besides estrogen …

Epidemiological, clinical, and experimental data indicate that the risk of developing breast
cancer is strongly dependent on the ovary and on endocrine conditions modulated by …

The purpose of this study was to investigate the effects of 17-β-estradiol (E2)-induced
reactive oxygen species (ROS) on the induction of mammary tumorigenesis. We found that …

Epidemiological studies have repeatedly demonstrated that women who undergo an early
first full-term pregnancy have a significantly reduced lifetime risk of breast cancer. Similarly …

Administration of a single iv injection of 50 mg N-methyl-N-nitrosourea (MNU)/kg body wt to
50-to 60-day-old virgin rats, 120-day-old virgin rats, and 120-day-old parous rats (Sprague …

One of the most consistent results in the epidemiology of human breast cancer is the inverse
relationship of risk and early full-term parity. The goal of this study was to investigate the …

Retinoids are well established chemopreventive agents for experimental carcinogenesis of
many target organs including mammary gland, urinary bladder, lung, skin, liver, pancreas …

We have postulated that the lifetime protective effect of an early pregnancy against breast
cancer is due to the complete differentiation of the mammary gland characterized by a …

The role of parity before and after N-methyl-N-nitrosourea (MNU) treatment in protection
against mammary carcinogenesis was investigated. The effect of lactation on reduction in …

Simple Summary Approximately 2.1 million women are affected by breast cancer every year.
Invasive disease accounts for 80% of breast cancer cases and is the most common and …