Abstract Preclinical Research Cellular proteins are the mediators of multiple organism
functions being involved in physiological mechanisms and disease. By discovering lead …

This paper provides an overview of recently developed two dimensional (2D) fragment-
based QSAR methods as well as other multi-dimensional approaches. In particular, we …

ABCB1 detoxifies cells by exporting diverse xenobiotic compounds, thereby limiting drug
disposition and contributing to multidrug resistance in cancer cells. Multiple small-molecule …

ABCG2 is an ATP-binding cassette (ABC) transporter whose function affects the
pharmacokinetics of drugs and contributes to multidrug resistance of cancer cells. While its …

P-glycoprotein (Pgp or ABCB1) is an ABC transporter protein involved in intestinal
absorption, drug metabolism, and brain penetration, and its inhibition can seriously alter a …

Many chemotherapeutics, such as paclitaxel, are administered intravenously as they suffer
from poor oral bioavailability, partly because of efflux mechanism of P-glycoprotein in the …

Multi-drug resistance (MDR) is a serious challenge in contemporary clinical practice and is
mostly responsible for the failure of cancer medication therapies. Several experimental …

With an aim to generate non-toxic, specific and highly potent multidrug resistance (MDR)
modulators, a novel series of anthranilic acid amide-substituted tariquidar derivatives were …

Herein, we report an electrochemically promoted chemoselective hydroxyl group
transformation for accessing tyrosine-containing biomolecules with valuable anthranilic acid …

As a pathological coagulation process, thrombus can lead to many serious diseases,
including ischemic stroke, acute myocardial infarction (AMI), acute coronary syndrome …