The primate prefrontal cortex (PFC) subserves our highest order cognitive operations, and
yet is tremendously dependent on a precise neurochemical environment for proper …

Many aspects of cognition and behaviour are regulated by noradrenergic projections to the
forebrain originating from the locus coeruleus, acting through alpha and beta …

Emotional arousal enhances perception and memory of high-priority information but impairs
processing of other information. Here, we propose that, under arousal, local glutamate levels …

The prefrontal cortex (PFC)—the most evolved brain region—subserves our highest-order
cognitive abilities. However, it is also the brain region that is most sensitive to the detrimental …

The psychological concepts of working memory and attention are widely used in the
cognitive and neuroscientific literatures. Perhaps because of the interdisciplinary appeal of …

The primary purpose of this study was to examine, using meta-analytical techniques, the
differential effects of differing intensities of acute exercise on speed and accuracy of …

Mood, attention and motivation co-vary with activity in the neuromodulatory systems of the
brain to influence behaviour. These psychological states, mediated by neuromodulators …

Since the introduction of chlorpromazine and throughout the development of the new-
generation antipsychotic drugs (APDs) beginning with clozapine, the D 2 receptor has been …

As we grow older, we may grow wiser, but we can also experience memory loss and
cognitive slowing that can interfere with our daily routines. The cognitive neuroscience of …

Through a widespread efferent projection system, the locus coeruleus–noradrenergic
system supplies norepinephrine throughout the central nervous system. Initial studies …