Malaria pathogenesis

DA Milner - Cold Spring Harbor perspectives in …, 2018 - perspectivesinmedicine.cshlp.org
In the mosquito–human life cycle, the six species of malaria parasites infecting humans
(Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale wallickeri, Plasmodium …

The immunological balance between host and parasite in malaria

K Deroost, TT Pham, G Opdenakker… - FEMS microbiology …, 2016 - academic.oup.com
Coevolution of humans and malaria parasites has generated an intricate balance between
the immune system of the host and virulence factors of the parasite, equilibrating maximal …

Malaria-associated atypical memory B cells exhibit markedly reduced B cell receptor signaling and effector function

S Portugal, CM Tipton, H Sohn, Y Kone, J Wang, S Li… - elife, 2015 - elifesciences.org
Protective antibodies in Plasmodium falciparum malaria are only acquired after years of
repeated infections. Chronic malaria exposure is associated with a large increase in atypical …

Immunity to malaria in an era of declining malaria transmission

FJI Fowkes, P Boeuf, JG Beeson - Parasitology, 2016 - cambridge.org
With increasing malaria control and goals of malaria elimination, many endemic areas are
transitioning from high-to-low-to-no malaria transmission. Reductions in transmission will …

[HTML][HTML] The role of different components of the immune system against Plasmodium falciparum malaria: Possible contribution towards malaria vaccine development

WL Mandala, V Harawa, F Dzinjalamala… - Molecular and …, 2021 - Elsevier
Plasmodium falciparum malaria still remains a major global public health challenge with
over 220 million new cases and well over 400,000 deaths annually. Most of the deaths occur …

Antibody responses to merozoite antigens after natural Plasmodium falciparum infection: kinetics and longevity in absence of re-exposure

V Yman, MT White, M Asghar, C Sundling, K Sondén… - BMC medicine, 2019 - Springer
Background Antibodies against merozoite antigens are key components of malaria
immunity. The naturally acquired antibody response to these antigens is generally …

The political ecology of landscape change, malaria, and cumulative vulnerability in central Ghana's gold mining country

D Ferring, H Hausermann - Annals of the American Association of …, 2019 - Taylor & Francis
Following the 2008 global financial crisis, small-scale gold mining operations proliferated
worldwide. Along Ghana's Offin River, the landscape has been radically transformed by …

Immune responses in malaria

CA Long, F Zavala - Cold Spring Harbor …, 2017 - perspectivesinmedicine.cshlp.org
Evidence accumulated through the years clearly indicates that antiparasite immune
responses can efficiently control malaria parasite infection at all development stages, and …

To B or not to B: understanding B cell responses in the development of malaria infection

ELV Silveira, MR Dominguez, IS Soares - Frontiers in immunology, 2018 - frontiersin.org
Malaria is a widespread disease caused mainly by the Plasmodium falciparum (Pf) and
Plasmodium vivax (Pv) protozoan parasites. Depending on the parasite responsible for the …

Identifying Plasmodium falciparum transmission patterns through parasite prevalence and entomological inoculation rate

B Amoah, RS McCann, AN Kabaghe, M Mburu… - Elife, 2021 - elifesciences.org
Background: Monitoring malaria transmission is a critical component of efforts to achieve
targets for elimination and eradication. Two commonly monitored metrics of transmission …