Abstract The 2020 Nobel Prize in Chemistry was awarded to Emmanuelle Charpentier and
Jennifer Doudna for the development of the Clustered regularly interspaced short …

Tumor suppressor genes cooperate with each other in tumors. Three important tumor
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …

Genes encoding SWI/SNF chromatin remodeling complex subunits are collectively mutated
in approximately 20% of human cancers. ARID1A is a SWI/SNF subunit gene whose protein …

Background Recent advances are enabling delivery of precision genomic medicine to
cancer clinics. While the majority of approaches profile panels of selected genes or hotspot …

The cytotoxic anti-cancer drugs cisplatin, paclitaxel, doxorubicin, 5-fluorouracil (5-FU), as
well as targeted drugs including imatinib, erlotinib, and nivolumab, play key roles in clinical …

Annexin A1 is a 37 kDa phospholipid-binding protein that is expressed in many tissues and
cell types, including leukocytes, lymphocytes and epithelial cells. Although Annexin A1 has …

NRF2 is a basic leucine zipper (bZip) transcription factor that is the master regulator of redox
homeostasis. Under basal conditions, the cellular level of NRF2 is low due to a …

Loss of the tumor suppressor gene CDKN2A, encoding p16 and p14, is a frequent event
driving melanoma progression. Therefore, therapeutic strategies aimed at CDKN2A loss …

Chemodynamic therapy (CDT) is an emerging treatment that usually employs chemical
agents to decompose hydrogen peroxide (H2O2) into hydroxyl radical (• OH) via Fenton or …

Prediction of driver genes (tumor suppressors and oncogenes) is an essential step in
understanding cancer development and discovering potential novel treatments. We recently …