The ADAMs (a disintegrin and metalloproteinase) are a fascinating family of transmembrane
and secreted proteins with important roles in regulating cell phenotype via their effects on …

The ADAMs family of transmembrane proteins belongs to the zinc protease superfamily.
Members of the family have a modular design, characterized by the presence of …

Amyloid β peptide (Aβ), the principal proteinaceous component of amyloid plaques in brains
of Alzheimer's disease patients, is derived by proteolytic cleavage of the amyloid precursor …

Innate immune responses are vital for pathogen defense but can result in septic shock when
excessive. A key mediator of septic shock is tumor necrosis factor–α (TNFα), which is shed …

Proteolytic enzymes belonging to the A Disintegin And Metalloproteinase (ADAM) family are
able to cleave transmembrane proteins close to the cell surface, in a process referred to as …

Notch signaling requires a series of proteolytic cleavage events to release the Notch
intracellular domain (NICD) that functions directly in signal transduction. The Notch receptor …

Human matrix metalloproteinases (MMPs) belong to the M10 family of the MA clan of
endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site …

Tumor necrosis factor (TNF)-related activation-induced cytokine (TRANCE), a member of the
TNF family, is a dendritic cell survival factor and is essential for osteoclastogenesis and …

Tumour necrosis factor α convertase (TACE) is a metalloprotease/disintegrin involved in the
ectodomain shedding of several proteins, a process thought to be important in inflammation …

The release of amyloidogenic amyloid-β peptide (Aβ) from amyloid-β precursor protein
(APP) requires cleavage by β-and γ-secretases. In contrast, α-secretase cleaves APP within …