Bone healing is a multifarious process involving mesenchymal stem cells, osteoprogenitor
cells, macrophages, osteoblasts and-clasts, and chondrocytes to restore the osseous tissue …

Ultrasound imaging is widely used to evaluate the neuromusculoskeletal system, and
recently, a particular interest is mounting in assessing the bone tissue and fractures …

WNT10B, a member of the WNT family of secreted glycoproteins, activates the WNT/β-
catenin signaling cascade to control proliferation, stemness, pluripotency, and cell fate …

While formation and regeneration of the skeleton have been studied for a long period of
time, significant scientific advances in this field continue to emerge based on an unmet …

Background Disordered and hypomineralized woven bone formation by dysfunctional
mesenchymal stromal cells (MSCs) characterize delayed fracture healing and endocrine …

Background Fracture nonunion/delayed union seriously affects physical and mental health
and quality of life. The aim of this study was to evaluate the relative efficacy of different …

Local immunoinflammatory events instruct skeletal stem cells (SSCs) to repair/regenerate
bone after injury, but mechanisms are incompletely understood. We hypothesized that …

The use of biomaterials and implants for joint replacement, fracture fixation, spinal
stabilization and other orthopedic indications has revolutionized patient care by reliably …

Atrophic nonunion (AN) is a complex and poorly understood pathological condition resulting
from impaired fracture healing. Advanced glycation end products (AGEs) have been …

The optimal balance between mechanical environment and biological factors is crucial for
successful bone healing, as they synergistically affect bone development. Any imbalance …