1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …

Phospholipase A 2 s are enzymes that hydrolyze the fatty acid at the sn-2 position of the
glycerol backbone of membrane glycerophospholipids. Given the asymmetric distribution of …

Ferroptosis, triggered by discoordination of iron, thiols and lipids, leads to the accumulation
of 15-hydroperoxy (Hp)-arachidonoyl-phosphatidylethanolamine (15-HpETE-PE), generated …

Summary Mutations in PLA2G6 (PARK14) cause neurodegenerative disorders in humans,
including autosomal recessive neuroaxonal dystrophy and early-onset parkinsonism. We …

Among the family of phospholipases A 2 (PLA 2 s) are the Ca 2+-independent PLA 2 s (iPLA
2 s) and they are designated group VI iPLA 2 s. In relation to secretory and cytosolic PLA 2 s …

Phospholipase A2 enzymes (PLA 2 s) comprise a superfamily that is generally divided into
six subfamilies known as cytosolic PLA 2 s (cPLA 2 s), calcium-independent PLA 2 s (iPLA 2 …

Arachidonic acid (AA) and its oxygenated derivatives, collectively known as the eicosanoids,
are key mediators of a wide variety of physiological and pathophysiological states. AA …

Peroxiredoxins (PRDXs) are antioxidant enzymes, known to catalyze peroxide reduction to
balance cellular hydrogen peroxide (H 2 O 2) levels, which are essential for cell signaling …

Perturbation of iron distribution is observed in many neurodegenerative disorders, including
Alzheimer's and Parkinson's disease, but the comprehension of the metal role in the …

Phospholipase A2 group VI (PLA2G6)-associated neurodegeneration (PLAN) includes a
series of neurodegenerative diseases that result from the mutations in PLA2G6. PLAN has …