There is a lack of new antibiotics to combat drug-resistant bacterial infections that
increasingly threaten global health. The current pipeline of clinical-stage antimicrobials is …

Highlights•A network of biogenesis pathways builds the Gram-negative bacterial cell
envelope.•ESRs monitor envelope integrity and biogenesis during normal growth and …

Surface sensing is a critical process that promotes the transition to a biofilm lifestyle. Several
surface-sensing mechanisms have been described for a range of species, most involving …

The predatory deltaproteobacterium Myxococcus xanthus uses a helically-trafficked motor at
bacterial focal-adhesion (bFA) sites to power gliding motility. Using total internal reflection …

The global public health burden of bacterial antimicrobial resistance (AMR) is intensified by
Gram-negative bacteria, which have an additional membrane, the outer membrane (OM) …

The β‐barrel assembly machinery (Bam) complex facilitates the assembly of outer
membrane proteins (OMPs) in gram‐negative bacteria. The Bam complex is conserved and …

Timely detection and repair of envelope damage are paramount for bacterial survival. The
Regulator of Capsule Synthesis (Rcs) stress response can transduce the stress signals …

Antibiotic resistance is a huge public health security crisis around the world. Darobactin is a
ribosomally produced and post-translationally modified heptapeptide antibiotic with a …

The Rcs pathway is repressed by the inner membrane protein IgaA under non-stressed
conditions. This repression is hypothesized to be relieved by the binding of the outer …

Multiple genetic changes in the enteric pathogen Yersinia pseudotuberculosis have driven
the emergence of Yesinia pestis, the arthropod-borne, etiological agent of plague. These …