The therapeutic areas of infectious diseases and oncology have benefited from abundant
scaffold diversity in natural products, able to interact with many specific targets within the cell …

Covering: 2005 to 2007 Natural product and natural product-derived compounds that are
being evaluated in clinical trials or are in registration (as at 31st December 2007) have been …

Antimicrobial chemotherapy has played a vital role in the treatment of human infectious
diseases since the discovery of penicillin in the 1920s. Hundreds of antimicrobial agents …

Recent clinical studies indicate that meropenem, a β-lactam antibiotic, is a promising
candidate for therapy of drug-resistant tuberculosis. However, meropenem is chemically …

Antimicrobials are the most frequently implicated class of drugs in drug‐induced seizure,
with β‐lactams being the class of antimicrobials most often implicated. The seizure‐inducing …

This review surveys the diversity of natural products (NPs) derived from terrestrial plants,
micro-organisms, marine organisms and fungi used in the treatment of various diseases. A …

Nature stands as an inexhaustible source of novel chemotypes and pharmacophores, and
has been a source of medicinal agents for thousands of years, and an impressive number of …

Background. The regimen of linezolid and moxifloxacin was found to be efficacious in the
hollow fiber system model of pediatric intracellular tuberculosis. However, its kill rate was …

Our experience during the years 2013 and 2014 mirrors their findings regarding this existing
risk for measles infection among travelers. Our Travel Clinic (TC) is a specialized service …

The β‐lactam classes of antibacterials are preeminent in the treatment of bacterial infection
due to their unparalleled clinical efficacy and clinical safety. Following the discovery of the …