Bacterial skin infections represent some of the most common infectious diseases globally.
Prevention and treatment of skin infections can involve application of a topical antimicrobial …

During microbial production of solvent-like compounds, such as advanced biofuels and bulk
chemicals, accumulation of the final product can negatively impact the cultivation of the host …

Using lignocellulosic biomass for the production of renewable biofuel provides a sustainable
and promising solution to the crisis of energy and environment. However, the processes of …

We set out to provide a resource to the microbiology community especially with respect to
systems biology based endeavors. To this end, we generated a comprehensive dataset …

The molecular mechanisms of ethanol toxicity and tolerance in bacteria, although important
for biotechnology and bioenergy applications, remain incompletely understood. Genetic …

Rapid profiling of stress-response at single-cell resolution yet in a label-free, non-disruptive
and mechanism-specific manner can lead to many new applications. We propose a single …

Genetic circuits implement computational operations within a cell. Debugging them is
difficult because their function is defined by multiple states (eg, combinations of inputs) that …

Highlights•Microbial metabolic engineering enables biochemical production at high
efficiency.•Bioprocessing of lignocellulose to products generates various toxic …

Highlights•Membrane disruption limits high titer production of biofuels and
biochemicals.•Strains evolved to have high tolerance maintain optimal membrane fluidity …

Clostridium thermocellum is a natively cellulolytic bacterium that is promising candidate for
cellulosic biofuel production, and can produce ethanol at high yields (75–80% of theoretical) …