miR-122 is a unique molecule with great potential in diagnosis, prognosis of liver disease, and therapy both as miRNA mimic and antimir
S Thakral, K Ghoshal - Current gene therapy, 2015 - ingentaconnect.com
miR-122, a completely conserved liver-specific miRNA in vertebrates, is essential for the
maintenance of liver homeostasis. This 22 nucleotide RNA regulates diverse functions such …
maintenance of liver homeostasis. This 22 nucleotide RNA regulates diverse functions such …
[HTML][HTML] Axl as a mediator of cellular growth and survival
H Axelrod, KJ Pienta - Oncotarget, 2014 - ncbi.nlm.nih.gov
The control of cellular growth and proliferation is key to the maintenance of homeostasis.
Survival, proliferation, and arrest are regulated, in part, by Growth Arrest Specific 6 (Gas6) …
Survival, proliferation, and arrest are regulated, in part, by Growth Arrest Specific 6 (Gas6) …
Akkermansia muciniphila prevents fatty liver disease, decreases serum triglycerides, and maintains gut homeostasis
S Kim, Y Lee, Y Kim, Y Seo, H Lee, J Ha… - Applied and …, 2020 - Am Soc Microbiol
The objective of this study was to elucidate the effect of intestinal Akkermansia muciniphila
bacteria on fatty liver disease. Five-week-old C57BL/6N mice were administered either …
bacteria on fatty liver disease. Five-week-old C57BL/6N mice were administered either …
MicroRNA 122, regulated by GRLH2, protects livers of mice and patients from ethanol-induced liver disease
Background & Aims Chronic, excessive alcohol consumption leads to alcoholic liver disease
(ALD) characterized by steatosis, inflammation, and eventually cirrhosis. The hepatocyte …
(ALD) characterized by steatosis, inflammation, and eventually cirrhosis. The hepatocyte …
[HTML][HTML] Mouse models of liver cancer: Progress and recommendations
L He, DA Tian, PY Li, XX He - Oncotarget, 2015 - ncbi.nlm.nih.gov
To clarify the pathogenesis of hepatocellular carcinoma (HCC) and investigate the effects of
potential therapies, a number of mouse models have been developed. Subcutaneous …
potential therapies, a number of mouse models have been developed. Subcutaneous …
MicroRNA-122 triggers mesenchymal-epithelial transition and suppresses hepatocellular carcinoma cell motility and invasion by targeting RhoA
SC Wang, XL Lin, J Li, TT Zhang, HY Wang, JW Shi… - PloS one, 2014 - journals.plos.org
The loss of microRNA-122 (miR-122) expression is strongly associated with increased
invasion and metastasis, and poor prognosis of hepatocellular carcinoma (HCC), however …
invasion and metastasis, and poor prognosis of hepatocellular carcinoma (HCC), however …
[HTML][HTML] Circulating microRNAs as markers of liver inflammation, fibrosis and cancer
C Roderburg, T Luedde - Journal of hepatology, 2014 - journal-of-hepatology.eu
Conclusion Despite their obvious potential as biomarkers, there are striking inter-study
variances of miRNA regulation patterns in patients with hepatic diseases. As key …
variances of miRNA regulation patterns in patients with hepatic diseases. As key …
Molecular targets and signaling pathways of microRNA-122 in hepatocellular carcinoma
KH Chun - Pharmaceutics, 2022 - mdpi.com
Hepatocellular carcinoma (HCC) is one of the leading global causes of cancer mortality.
MicroRNAs (miRNAs) are small interfering RNAs that alleviate the levels of protein …
MicroRNAs (miRNAs) are small interfering RNAs that alleviate the levels of protein …
Cerium oxide nanoparticles attenuate oxidative stress and inflammation in the liver of diethylnitrosamine-treated mice
The catalytic activity of cerium oxide nanoparticles (CeO2NPs) is responsible for its
application as an antitumor agent. This activity may be due to its ability to switch between III …
application as an antitumor agent. This activity may be due to its ability to switch between III …
Dysregulated miRNA in progression of hepatocellular carcinoma: A systematic review
Y Mizuguchi, T Takizawa, H Yoshida… - Hepatology …, 2016 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the fifth most frequent cancer and the third cause of
cancer‐related mortality worldwide. The primary risk factor for HCC is liver cirrhosis …
cancer‐related mortality worldwide. The primary risk factor for HCC is liver cirrhosis …