miR-122 is a unique molecule with great potential in diagnosis, prognosis of liver disease, and therapy both as miRNA mimic and antimir

S Thakral, K Ghoshal - Current gene therapy, 2015 - ingentaconnect.com
miR-122, a completely conserved liver-specific miRNA in vertebrates, is essential for the
maintenance of liver homeostasis. This 22 nucleotide RNA regulates diverse functions such …

[HTML][HTML] Axl as a mediator of cellular growth and survival

H Axelrod, KJ Pienta - Oncotarget, 2014 - ncbi.nlm.nih.gov
The control of cellular growth and proliferation is key to the maintenance of homeostasis.
Survival, proliferation, and arrest are regulated, in part, by Growth Arrest Specific 6 (Gas6) …

Akkermansia muciniphila prevents fatty liver disease, decreases serum triglycerides, and maintains gut homeostasis

S Kim, Y Lee, Y Kim, Y Seo, H Lee, J Ha… - Applied and …, 2020 - Am Soc Microbiol
The objective of this study was to elucidate the effect of intestinal Akkermansia muciniphila
bacteria on fatty liver disease. Five-week-old C57BL/6N mice were administered either …

MicroRNA 122, regulated by GRLH2, protects livers of mice and patients from ethanol-induced liver disease

A Satishchandran, A Ambade, S Rao, YC Hsueh… - Gastroenterology, 2018 - Elsevier
Background & Aims Chronic, excessive alcohol consumption leads to alcoholic liver disease
(ALD) characterized by steatosis, inflammation, and eventually cirrhosis. The hepatocyte …

[HTML][HTML] Mouse models of liver cancer: Progress and recommendations

L He, DA Tian, PY Li, XX He - Oncotarget, 2015 - ncbi.nlm.nih.gov
To clarify the pathogenesis of hepatocellular carcinoma (HCC) and investigate the effects of
potential therapies, a number of mouse models have been developed. Subcutaneous …

MicroRNA-122 triggers mesenchymal-epithelial transition and suppresses hepatocellular carcinoma cell motility and invasion by targeting RhoA

SC Wang, XL Lin, J Li, TT Zhang, HY Wang, JW Shi… - PloS one, 2014 - journals.plos.org
The loss of microRNA-122 (miR-122) expression is strongly associated with increased
invasion and metastasis, and poor prognosis of hepatocellular carcinoma (HCC), however …

[HTML][HTML] Circulating microRNAs as markers of liver inflammation, fibrosis and cancer

C Roderburg, T Luedde - Journal of hepatology, 2014 - journal-of-hepatology.eu
Conclusion Despite their obvious potential as biomarkers, there are striking inter-study
variances of miRNA regulation patterns in patients with hepatic diseases. As key …

Molecular targets and signaling pathways of microRNA-122 in hepatocellular carcinoma

KH Chun - Pharmaceutics, 2022 - mdpi.com
Hepatocellular carcinoma (HCC) is one of the leading global causes of cancer mortality.
MicroRNAs (miRNAs) are small interfering RNAs that alleviate the levels of protein …

Cerium oxide nanoparticles attenuate oxidative stress and inflammation in the liver of diethylnitrosamine-treated mice

OA Adebayo, O Akinloye, OA Adaramoye - Biological trace element …, 2020 - Springer
The catalytic activity of cerium oxide nanoparticles (CeO2NPs) is responsible for its
application as an antitumor agent. This activity may be due to its ability to switch between III …

Dysregulated miRNA in progression of hepatocellular carcinoma: A systematic review

Y Mizuguchi, T Takizawa, H Yoshida… - Hepatology …, 2016 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the fifth most frequent cancer and the third cause of
cancer‐related mortality worldwide. The primary risk factor for HCC is liver cirrhosis …