Despite daily fasting and feeding, plasma glucose levels are normally maintained within a
narrow range owing to the hormones insulin and glucagon. Insulin increases glucose …

In muscle and fat cells, insulin stimulates the delivery of the glucose transporter GLUT4 from
an intracellular location to the cell surface, where it facilitates the reduction of plasma …

Targeting organelles by modulating the redox potential of mitochondria is a promising
approach to kill cancer cells that minimizes acquired drug resistance. However, it lacks …

Herein, we show intranuclear nanoribbons formed upon dephosphorylation of leucine‐rich L‐
or D‐phosphopeptide catalyzed by alkaline phosphatase (ALP) to selectively kill …

Tumor cell lines are often used as models for the study of nanoparticle− cell interactions.
Here we demonstrate that carboxy (PS-COOH) and amino functionalized (PS-NH2) …

Endocytosis of cell surface receptors is an important regulatory event in signal transduction.
The transforming growth factor β (TGF-β) superfamily signals to the Smad pathway through …

Among the membrane compartments of a cell, vesicles known as “caveolae” have long
defied functional characterization. However, since the identification of a family of proteins …

Eukaryotic cells constantly form and internalize plasma membrane vesicles in a process
known as endocytosis. Endocytosis serves a variety of housekeeping and specialized …

EGF receptor (EGFR) overexpression correlates with metastasis in a variety of carcinomas,
but the underlying mechanisms are poorly understood. We demonstrated that EGF disrupted …

Despite remarkable progress in dissecting the signaling pathways that are crucial for the
metabolic effects of insulin, the molecular basis for the specificity of its cellular actions is not …