(1) Background: Scleroderma (Sc) is a rare connective tissue disease classified as an
autoimmune disorder. The pathogenesis of this disease is not fully understood.(2) Methods …

Systemic sclerosis (SSc) is a severe autoimmune disease that is characterized by vascular
abnormalities, immunological alterations and fibrosis of the skin and internal organs. The …

Systemic sclerosis is an autoimmune disease leading to vasculopathy and fibrosis of skin
and internal organs. Despite likely shared pathogenic mechanisms, the patterns of skin and …

Systemic sclerosis (SSc) is associated with high mortality owing to internal organ
complications, and lung disease is the leading cause of SSc-associated death. The most …

Background Pulmonary fibrosis is a fatal lung disease with complex pathogenesis and
limited effective therapies. Salt-inducible kinase 2 (SIK2) is a kinase that phosphorylates …

Systemic sclerosis (SSc) is an autoimmune disorder characterized by vascular damage,
excessive fibrosis and abnormal T cells immune-regulation. CD146 is an adhesion molecule …

Cryptotanshinone (CTS) was reported to repress a variety of systemic inflammation and
alleviate cardiac fibrosis, but it is still unclear whether CTS could prevent radiation‐induced …

The extracellular matrix (ECM) is critical in all aspects of vascular development and health:
supporting cell anchorage, providing structure, organization and mechanical stability, and …

Systemic sclerosis (SSc) is a chronic progressive autoimmune disease characterized by
immune inflammation, vasculopathy, and fibrosis. There are still numerous uncertainties in …

Systemic sclerosis (SSc) is a rare disease with a prevalence ranging from 7 to 700 cases per
million. Like with most autoimmune diseases, both environmental and genetic factors are …