Natural cytotoxicity receptors (NCRs) have been classically defined as activating receptors
delivering potent signals to Natural Killer (NK) cells in order to lyze harmful cells and to …

Natural killer (NK) cells are important effectors of innate immunity playing a key role in the
eradication and clearance of viral infections. Over the recent years, several studies have …

Many pathogens evade cytotoxic T lymphocytes (CTLs) by downregulating HLA molecules
on infected cells, but the loss of HLA can trigger NK cell-mediated lysis. HIV-1 is thought to …

Current efforts toward human immunodeficiency virus (HIV) eradication include approaches
to augment immune recognition and elimination of persistently infected cells following …

Natural killer (NK) cell degranulation in response to virus-infected cells is triggered by
interactions between invariant NK cell surface receptors and their ligands on target cells …

HIV up-regulates cell-surface expression of specific ligands for the activating NKG2D
receptor, including ULBP-1,-2, and-3, but not MICA or MICB, in infected cells both in vitro …

Invariant NKT cells are important in the activation and regulation of immune responses. They
can also function as CD1d‐restricted killer cells. However, the role of activating innate NK …

The human immunodeficiency virus type 1 (HIV-1) evades the immune responses of natural
killer (NK) cells through mechanisms that have been partially deciphered. Here we show …

Natural killer (NK) cells are innate cytolytic effectors that target HIV-infected CD4+ T cells. In
conjunction with antibodies recognizing the HIV envelope, NK cells also eliminate HIV …

Classically, natural killer (NK) cells have been defined by nonspecific innate killing of virus-
infected and tumor cells. However, burgeoning evidence suggests that the functional …