Acute respiratory distress syndrome: causes, pathophysiology, and phenotypes

LDJ Bos, LB Ware - The Lancet, 2022 - thelancet.com
Acute respiratory distress syndrome (ARDS) is a common clinical syndrome of acute
respiratory failure as a result of diffuse lung inflammation and oedema. ARDS can be …

Pathogenesis of pneumonia and acute lung injury

ME Long, RK Mallampalli, JC Horowitz - Clinical Science, 2022 - portlandpress.com
Pneumonia and its sequelae, acute lung injury, present unique challenges for pulmonary
and critical care healthcare professionals, and these challenges have recently garnered …

[HTML][HTML] Longitudinal profiling of respiratory and systemic immune responses reveals myeloid cell-driven lung inflammation in severe COVID-19

PA Szabo, P Dogra, JI Gray, SB Wells, TJ Connors… - Immunity, 2021 - cell.com
Immune response dynamics in coronavirus disease 2019 (COVID-19) and their severe
manifestations have largely been studied in circulation. Here, we examined the relationship …

Macrophages in lung injury, repair, and fibrosis

P Cheng, S Li, H Chen - Cells, 2021 - mdpi.com
Fibrosis progression in the lung commonly results in impaired functional gas exchange,
respiratory failure, or even death. In addition to the aberrant activation and differentiation of …

Macrophage polarization and its role in the pathogenesis of acute lung injury/acute respiratory distress syndrome

X Chen, J Tang, W Shuai, J Meng, J Feng, Z Han - Inflammation Research, 2020 - Springer
Purpose Macrophages are highly plastic cells. Under different stimuli, macrophages can be
polarized into several different subsets. Two main macrophage subsets have been …

Acute respiratory distress syndrome

BT Thompson, RC Chambers… - New England Journal of …, 2017 - Mass Medical Soc
Acute Respiratory Distress Syndrome | New England Journal of Medicine Skip to main content
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Pathogenesis of acute respiratory distress syndrome

LA Huppert, MA Matthay… - Seminars in respiratory and …, 2019 - thieme-connect.com
Acute respiratory distress syndrome (ARDS) is a syndrome of acute respiratory failure
caused by noncardiogenic pulmonary edema. Despite five decades of basic and clinical …

The role of macrophages in the development of acute and chronic inflammatory lung diseases

JW Lee, W Chun, HJ Lee, JH Min, SM Kim, JY Seo… - Cells, 2021 - mdpi.com
Macrophages play an important role in the innate and adaptive immune responses of organ
systems, including the lungs, to particles and pathogens. Cumulative results show that …

Myc cooperates with Ras by programming inflammation and immune suppression

RM Kortlever, NM Sodir, CH Wilson, DL Burkhart… - Cell, 2017 - cell.com
The two oncogenes KRas and Myc cooperate to drive tumorigenesis, but the mechanism
underlying this remains unclear. In a mouse lung model of KRas G12D-driven adenomas …

The role of macrophages in the pathogenesis of ALI/ARDS

X Huang, H Xiu, S Zhang, G Zhang - Mediators of inflammation, 2018 - Wiley Online Library
Despite development in the understanding of the pathogenesis of acute lung injury
(ALI)/acute respiratory distress syndrome (ARDS), the underlying mechanism still needs to …