The AID/APOBEC polynucleotide cytidine deaminases have historically been classified as
either DNA mutators or RNA editors based on their first identified nucleic acid substrate …

The APOBEC family of single-stranded DNA cytosine deaminases comprises a formidable
arm of the vertebrate innate immune system. Pre-vertebrates express a single APOBEC …

Deep sequencing technologies are revealing the complexities of cancer evolution, casting
light on mutational processes fueling tumor adaptation, immune escape, and treatment …

Rational development of targeted therapies has revolutionized metastatic breast cancer
outcomes, although resistance to treatment remains a major challenge. Advances in …

A role for somatic mutations in carcinogenesis is well accepted, but the degree to which
mutation rates influence cancer initiation and development is under continuous debate …

Non-small cell lung cancer (NSCLC) is known to carry heavy mutation load. Besides
smoking, cytidine deaminase APOBEC3B plays a key role in the mutation process of …

The initiation, progression, and relapse of cancers often result from mutations occurring
within somatic cells. Consequently, processes that elevate mutation rates accelerate …

To replicate in their hosts, viruses have to navigate the complexities of the mammalian cell,
co-opting mechanisms of cellular physiology while defeating restriction factors that are …

APOBEC family cytidine deaminases have recently been implicated as powerful mutators of
cancer genomes. How APOBECs, which are ssDNA-specific enzymes, gain access to …

APOBEC cytidine deaminases are the second-most prominent source of mutagenesis in
sequenced tumors. Previous studies have proposed that APOBEC3B (A3B) is the major …