Studies of the genetics of psychiatric disorders have become one of the most exciting and
fast-moving areas in human genetics. A decade ago, there were few reproducible findings …

Increasing evidence points to a central role for immune dysregulation in autism spectrum
disorder (ASD). Several ASD risk genes encode components of the immune system and …

Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial
public health impact. We conducted a multi-stage genome-wide association study (GWAS) …

Genetic studies have identified dozens of autism spectrum disorder (ASD) susceptibility
genes, raising two critical questions:(1) do these genetic loci converge on specific biological …

Rare copy-number variation (CNV) is an important source of risk for autism spectrum
disorders (ASDs). We analyzed 2,446 ASD-affected families and confirmed an excess of …

Autism spectrum disorder (autism) is a heterogeneous group of neurodevelopmental
conditions characterized by early childhood-onset impairments in communication and social …

We assessed gene expression profiles in 2,752 twins, using a classic twin design to quantify
expression heritability and quantitative trait loci (eQTLs) in peripheral blood. The most highly …

The canonical paradigm for converting genetic association to mechanism involves iteratively
mapping individual associations to the proximal genes through which they act. In contrast, in …

Reciprocal deletion and duplication of the 16p11. 2 region is the most common copy number
variation (CNV) associated with autism spectrum disorders. We generated cortical organoids …

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