Cell–cell junctions link cells to each other in tissues, and regulate tissue homeostasis in
critical cell processes that include tissue barrier function, cell proliferation, and migration …

Desmosomal cadherins are a recent evolutionary innovation that make up the adhesive core
of highly specialized intercellular junctions called desmosomes. Desmosomal cadherins …

Desmosomes are intercellular junctions, which preserve tissue integrity during homeostatic
and stress conditions. These functions rely on their unique structural properties, which …

Adherens junctions (AJs) and desmosomes connect the actin and keratin filament networks
of adjacent cells into a mechanical unit. Whereas AJs function in mechanosensing and in …

The development of adhesive connections between cells was critical for the evolution of
multicellularity and for organizing cells into complex organs with discrete compartments …

This review discusses the spectrin superfamily of proteins that function to connect
cytoskeletal elements to each other, the cell membrane, and the nucleus. The signature …

Canonical Wnt signaling is emerging as a major regulator of endocytosis. Wnt treatment
markedly increased the endocytosis and degradation in lysosomes of BSA. In this study, we …

Desmosomes are relatives of ancient cadherin-based junctions, which emerged late in
evolution to ensure the structural integrity of vertebrate tissues by coupling the intermediate …

Myofibril breakdown is a fundamental cause of muscle wasting and inevitable sequel of
aging and disease. We demonstrated that myofibril loss requires depolymerization of the …

The translation of mechanical forces into biochemical signals plays a central role in guiding
normal physiological processes during tissue development and homeostasis. Interfering …