Crohn's disease (CD) is an inflammatory bowel disease (IBD) with repeated remissions and
relapses. As the disease progresses, fibrosis and narrowing of the intestine occur, leading to …

Crohn's disease (CD) and ulcerative colitis (UC) are inflammatory bowel diseases (IBD) with
the involvement of immune cells and molecules, including cytokines, chemokines and …

Differential diagnosis of inflammatory bowel disease (IBD) to Crohn's disease (CD) or
ulcerative colitis (UC) is crucial for treatment decision making. With the aim of generating a …

Biological mediators secreted during peripheral chronic inflammation reach the bloodstream
and may damage the blood–brain barrier (BBB), triggering central nervous system (CNS) …

In this study, we explored the potential beneficial effects of green tea extract (GTE) in a
pathogenic Escherichia coli (F18: LT: STa: Stx2e)-induced colitis model. The GTE was …

Background Hirschsprung's disease (HSCR) is a relatively common congenital disability.
Accumulating extracellular matrix (ECM) prompts intestinal fibrosis remodelling in the …

This year marks the 35th anniversary of Professor Walter Wahli's discovery of the PPARs
(Peroxisome Proliferator-Activated Receptors) family of nuclear hormone receptors. To mark …

Pioglitazone shows potential benefits in inflammatory bowel disease (IBD) in preclinical
studies, but its effect in humans has not been researched. We used a nationwide database …

Introduction Current medications for autoimmune disorders often induce broad-ranging side
effects, prompting a growing interest in therapies with more specific immune system …

Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that sense
lipophilic molecules and act as transcription factors to regulate target genes. PPARs have …