Opioid-induced respiratory depression (OIRD) represents the primary cause of death
associated with therapeutic and recreational opioid use. Within the United States, the rate of …

Voltage gated calcium channels (Ca2+ channels) are key mediators of depolarization
induced calcium influx into excitable cells, and thereby play pivotal roles in a wide array of …

Acute modulation of P/Q-type (α1A) calcium channels by neuronal activity-dependent
changes in intracellular Ca2+ concentration may contribute to short-term synaptic plasticity …

The properties of synaptic transmission were first elucidated at the neuromuscular junction.
More recent work has examined transmission at synapses within the brain. Here we review …

The regulation of presynaptic, voltage-gated calcium channels by activation of heptahelical
G protein-coupled receptors exerts a crucial influence on presynaptic calcium entry and …

Recombinant adenoviruses were used to overexpress green fluorescent protein (GFP)‐
fused auxiliary Ca2+ channel β subunits (β1‐β4) in cultured adult rat heart cells, to explore …

A key step in the release of neurotransmitter is the entry of Ca 2+ into the presynaptic
terminal via voltage-activated Ca 2+ channels. N-type and P/Q-type Ca 2+ channels play a …

Potassium leak channels are essential to neurophysiological function. Leaks suppress
excitability through maintenance of resting membrane potential below the threshold for …

The axon is responsible for integrating synaptic signals, generating action potentials (APs),
propagating those APs to downstream synapses and converting them into patterns of …

Opioid-induced respiratory depression (OIRD) is the major cause of death associated with
opioid analgesics and drugs of abuse, but the underlying cellular and molecular …