Lymphangioleiomyomatosis: pathogenesis, clinical features, diagnosis, and management

C McCarthy, N Gupta, SR Johnson, JY Jane… - The Lancet …, 2021 - thelancet.com
Lymphangioleiomyomatosis (LAM) is a slowly progressive, low-grade, metastasising
neoplasm of women, characterised by infiltration of the lung parenchyma with abnormal …

PEComa: morphology and genetics of a complex tumor family

K Thway, C Fisher - Annals of diagnostic pathology, 2015 - Elsevier
Perivascular epithelioid cell tumors, or PEComas, are mesenchymal neoplasms composed
of histologically and immunohistochemically distinctive epithelioid or spindle cells, which are …

Efficacy and safety of sirolimus in lymphangioleiomyomatosis

FX McCormack, Y Inoue, J Moss… - … England Journal of …, 2011 - Mass Medical Soc
Background Lymphangioleiomyomatosis (LAM) is a progressive, cystic lung disease in
women; it is associated with inappropriate activation of mammalian target of rapamycin …

Official American Thoracic Society/Japanese Respiratory Society clinical practice guidelines: lymphangioleiomyomatosis diagnosis and management

FX McCormack, N Gupta, GR Finlay… - American journal of …, 2016 - atsjournals.org
Background: Lymphangioleiomyomatosis (LAM) is a rare cystic lung disease that primarily
affects women. The purpose of these guidelines is to provide recommendations for the …

[HTML][HTML] Lymphangioleiomyomatosis—a wolf in sheep's clothing

EP Henske, FX McCormack - The Journal of clinical …, 2012 - Am Soc Clin Investig
Lymphangioleiomyomatosis (LAM) is a rare progressive lung disease of women. LAM is
caused by mutations in the tuberous sclerosis genes, resulting in activation of the mTOR …

Perivascular epithelioid cell neoplasms: pathology and pathogenesis

AL Folpe, DJ Kwiatkowski - Human pathology, 2010 - Elsevier
Perivascular epithelioid cell neoplasms: pathology and pathogenesis - ScienceDirect Skip
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[HTML][HTML] Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment

Y Tang, DJ Kwiatkowski, EP Henske - Nature communications, 2022 - nature.com
Abstract mTORC1 is hyperactive in multiple cancer types,. Here, we performed integrative
analysis of single cell transcriptomic profiling, paired T cell receptor (TCR) sequencing, and …

From the archives of the AFIP: primary vascular neoplasms of the spleen: radiologic-pathologic correlation

RM Abbott, AD Levy, NS Aguilera, L Gorospe… - Radiographics, 2004 - pubs.rsna.org
Primary vascular neoplasms of the spleen constitute the majority of nonhematolymphoid
splenic tumors. The benign primary vascular tumors include hemangioma, hamartoma, and …

Molecular biology and pathology of lymphangiogenesis

T Karpanen, K Alitalo - Annu. Rev. Pathol. Mech. Dis., 2008 - annualreviews.org
The lymphatic vasculature is essential for the maintenance of tissue fluid balance, immune
surveillance, and adsorption fatty acids in the gut. The lymphatic vessels are also crucially …

Diffuse cystic lung disease. Part I

N Gupta, R Vassallo… - American journal of …, 2015 - atsjournals.org
The diffuse cystic lung diseases (DCLDs) are a group of pathophysiologically heterogenous
processes that are characterized by the presence of multiple spherical or irregularly shaped …