Single‐cell RNA sequencing (scRNA‐seq) technology has become the state‐of‐the‐art
approach for unravelling the heterogeneity and complexity of RNA transcripts within …

The generation of islet-like endocrine clusters from human pluripotent stem cells (hPSCs)
has the potential to provide an unlimited source of insulin-producing β cells for the treatment …

Transplantation of pancreatic islet cells derived from human pluripotent stem cells is a
promising treatment for diabetes. Despite progress in the generation of stem-cell-derived …

We detail a six-stage planar differentiation methodology for generating human pluripotent
stem cell–derived pancreatic β cells (SC-β cells) that secrete high amounts of insulin in …

Human pluripotent stem-cell-derived islets (hPSC-islets) are a promising cell resource for
diabetes treatment,. However, this therapeutic strategy has not been systematically …

Insulin-producing β cells created from human pluripotent stem cells have potential as a
therapy for insulin-dependent diabetes, but human pluripotent stem cell-derived islets (SC …

Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …

Immunological protection of transplanted stem cell-derived islet (SC-islet) cells is yet to be
achieved without chronic immunosuppression or encapsulation. Existing genetic …

Diabetes involves the death or dysfunction of pancreatic β-cells. Analysis of bulk sequencing
from human samples and studies using in vitro and in vivo models suggest that endoplasmic …

Pancreatic islet cells derived from human pluripotent stem cells hold great promise for
modeling and treating diabetes. Differences between stem-cell-derived and primary islets …