The past decade has seen many advancements in the development of three-dimensional
(3D) in vitro models in pharmaceutical sciences and industry. Specifically, organoids present …

Simple Summary Hepatocellular carcinoma (HCC) is a highly incident and deadly malignant
neoplasia, and only a few anti-HCC drugs are currently available. Thus, the development of …

Preclinical models of cancer based on the use of human cancer cell lines and mouse
models have enabled discoveries that have been successfully translated into patients. And …

Primary liver cancers (PLC), including hepatocellular carcinoma (HCC) and
cholangiocarcinoma (CCA), are among the leading causes of cancer-related mortality …

Hepatocellular carcinoma is one of the malignancies worldwide with a high mortality rate
and an increasing incidence. Molecular Targeted agents are its common first-line treatment …

The development and function of a particular organ and the pathogenesis of various
diseases remain intimately linked to the features of each cell type in the organ. Conventional …

Intrahepatic cholangiocarcinoma (CCA), always diagnosed at an advanced stage in recent
years, is of high aggression and poor prognosis. There is no standard treatment beyond first …

Hepatocellular carcinoma accounts for the majority proportion of primary liver cancer and it
is the fourth leading cause of cancer-related mortality in the world, while multifactorial drug …

Background Tumor-derived organoid, namely tumoroid, can realistically retain the
clinicopathologic features of original tumors even after long-term in vitro expansion. Here we …

The liver is the main metabolic organ and functions to regulate many physiological functions
in the human body. Approximately 70% of liver mass consists of hepatic cells (hepatocytes) …