Inflammasomes are multiprotein complexes that activate inflammatory cytokines and induce
pyroptosis in response to intracellular danger‐associated signals. NLRP1 and CARD8 are …

Inflammasomes are cytosolic multiprotein complexes that assemble in response to a variety
of infectious and noxious insults. Inflammasomes play a critical role in the initiation of innate …

The pathogenesis of Bacillus anthracis, the bacterium that causes anthrax, depends on
secretion of three factors that combine to form two bipartite toxins. Edema toxin, consisting of …

Inflammasomes are cytosolic protein complexes that serve as platforms for the recruitment
and activation of the pro‐inflammatory CASPASE‐1 protease. CASPASE‐1 activation leads …

The tripartite toxin secreted by Bacillus anthracis, the causative agent of anthrax, helps the
bacterium evade the immune system and can kill the host during a systemic infection. Two …

Inflammasomes are multimeric protein complexes that respond to infection by recruitment
and activation of the Caspase-1 (CASP1) protease. Activated CASP1 initiates immune …

Microbial pathogens possess an arsenal of strategies to invade their hosts, evade immune
defences and promote infection. In particular, bacteria use virulence factors, such as …

Lethal factor (LF) is a protein (relative molecular mass 90,000) that is critical in the
pathogenesis of anthrax,,. It is a highly specific protease that cleaves members of the …

Comparison of the anthrax toxin lethal factor (LF) amino acid sequence with sequences in
the Swiss protein database revealed short regions of similarity with the consensus zinc …

Anthrax lethal toxin (LT) and edema toxin (ET) are the major virulence factors of anthrax and
can replicate the lethality and symptoms associated with the disease. This review provides …