▪ Abstract Src family protein tyrosine kinases are activated following engagement of many
different classes of cellular receptors and participate in signaling pathways that control a …

▪ Abstract The 3-phosphorylated inositol lipids fulfill roles as second messengers by
interacting with the lipid binding domains of a variety of cellular proteins. Such interactions …

The Ras-dependent activation of mitogen-activated protein (MAP) kinase pathways by many
receptors coupled to heterotrimeric guanine nucleotide binding proteins (G proteins) …

THE paired helical filament (PHF) is the major component of the neurofibrillary deposits that
form a defining neuropathological characteristic of Alzheimer's disease (reviewed in refs 1 …

Many of the G-protein-coupled receptors for hormones that bind to the cell surface can
signal to the interior of the cell through several different classes of G protein,,,. For example …

Adhesive interactions play critical roles in directing the migration, proliferation, and
differentiation of cells; aberrations in such interactions can lead to pathological disorders …

Abstract Ossovskaya, Valeria S., and Nigel W. Bunnett. Protease-Activated Receptors:
Contribution to Physiology and Disease. Physiol Rev 84: 579–621, 2004; 10.1152/physrev …

Src is the best understood member of a family of 9 tyrosine kinases that regulates cellular
responses to extracellular stimuli. Activated mutants of Src are oncogenic. Using Src as an …

Proteinase-activated receptors are a recently described, novel family of seven-
transmembrane G-protein-coupled receptors. Rather then being stimulated through ligand …

Many signaling pathways converge on and regulate phosphoinositide 3-kinase (PI3K)
enzymes whose inositol lipid products are key mediators of intracellular signaling. Different …