Posttranslational modification with small ubiquitin-related modifier (SUMO) proteins is now
established as one of the key regulatory protein modifications in eukaryotic cells. Hundreds …

Both ubiquitination and SUMOylation are dynamic post-translational modifications that
regulate thousands of target proteins to control virtually every cellular process …

At a first glance, ribosome biogenesis and chromatin remodeling are quite different
processes, but they share a common problem involving interactions between charged …

Mammalian cells that sustain oncogenic insults can invoke defensive programmes that
either halt their division or trigger their apoptosis, but these countermeasures must be finely …

Nucleophosmin (NPM, also known as B23, numatrin or NO38) is a ubiquitously expressed
phosphoprotein belonging to the nucleoplasmin family of chaperones. NPM is mainly …

SUMOylation governs numerous cellular processes and is essential to most eukaryotic life.
Despite increasing recognition of the importance of this process, an extremely limited …

The use of biomarkers ensures breast cancer patients receive optimal treatment.
Established biomarkers such as estrogen receptor (ER) and progesterone receptor (PR) …

Simple Summary The small ubiquitin-like modifier (SUMO) pathway regulates the hallmark
properties of cancer cells. Moreover, alterations in activity and in levels of SUMO machinery …

Anti-tumorigenic mechanisms mediated by the tumor suppressor p53, upon oncogenic
stresses, are our bodies' greatest weapons to battle against cancer onset and development …

Abstract NPM1/Nucleophosmin/B23, also termed NO38 or numatrin, is an acidic nucleolar
protein that plays multiple roles in cell growth and proliferation. In general, the expression …