The important role of ligand–receptor binding kinetics in drug design and discovery is
increasingly recognized by the drug research community. Over the past decade …

The peptide quantitative structure–activity relationship (QSAR), also known as the
quantitative sequence–activity model (QSAM), has attracted much attention in the bio-and …

Cell signal networks are orchestrated directly or indirectly by various peptide-mediated
protein–protein interactions, which are normally weak and transient and thus ideal for …

Many cell signaling pathways are orchestrated by the weak, transient, and reversible protein–
protein interactions that are mediated by the binding of a short peptide segment in one …

Previously, we have reported a new biomolecular phenomenon spanning between protein
folding and binding, termed as self-binding peptides (SBPs), where a short peptide segment …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an etiological agent of
the current rapidly growing outbreak of coronavirus disease (COVID-19), which is straining …

Proto-oncogene non-receptor tyrosine protein kinase c-Src has been involved in the
development, progression and metastasis of a variety of human cancers. This protein …

Abstract Src homology 3 (SH3) domains are small protein modules involved in the
regulation of important cellular pathways such as proliferation and migration, which …

Self-binding peptide (SBP) represents a novel biomolecular phenomenon spanning
between folding and binding. It is a structurally independent, short peptide segment within a …

The interaction event between programmed death receptor-1 (PD-1) and its ligand (PD-L1)
functions as an essential immune checkpoint against cytotoxic T effector cell activation …