Olfactory ensheathing cells for spinal cord injury: sniffing out the issues

R Yao, M Murtaza, JT Velasquez… - Cell …, 2018 - journals.sagepub.com
Olfactory ensheathing cells (OECs) are glia reported to sustain the continuous axon
extension and successful topographic targeting of the olfactory receptor neurons …

Multi-target approaches to CNS repair: olfactory mucosa-derived cells and heparan sulfates

SL Lindsay, GA McCanney, AG Willison… - Nature Reviews …, 2020 - nature.com
Spinal cord injury (SCI) remains one of the biggest challenges in the development of
neuroregenerative therapeutics. Cell transplantation is one of numerous experimental …

Chlamydia pneumoniae can infect the central nervous system via the olfactory and trigeminal nerves and contributes to Alzheimer's disease risk

A Chacko, A Delbaz, H Walkden, S Basu… - Scientific reports, 2022 - nature.com
Chlamydia pneumoniae is a respiratory tract pathogen but can also infect the central
nervous system (CNS). Recently, the link between C. pneumoniae CNS infection and late …

Phagocytosis by peripheral glia: Importance for nervous system functions and implications in injury and disease

L Nazareth, J St John, M Murtaza… - Frontiers in Cell and …, 2021 - frontiersin.org
The central nervous system (CNS) has very limited capacity to regenerate after traumatic
injury or disease. In contrast, the peripheral nervous system (PNS) has far greater capacity …

Olfactory ensheathing cells are the main phagocytic cells that remove axon debris during early development of the olfactory system

L Nazareth, KE Lineburg, MI Chuah… - Journal of …, 2015 - Wiley Online Library
During development of the primary olfactory system, axon targeting is inaccurate and axons
inappropriately project within the target layer or overproject into the deeper layers of the …

Burkholderia pseudomallei penetrates the brain via destruction of the olfactory and trigeminal nerves: implications for the pathogenesis of neurological melioidosis

JA St. John, JAK Ekberg, SJ Dando, ACB Meedeniya… - MBio, 2014 - Am Soc Microbiol
Melioidosis is a potentially fatal disease that is endemic to tropical northern Australia and
Southeast Asia, with a mortality rate of 14 to 50%. The bacterium Burkholderia pseudomallei …

The migration of olfactory ensheathing cells during development and regeneration

JAK Ekberg, D Amaya, A Mackay-Sim, JA St. John - Neurosignals, 2012 - karger.com
The primary olfactory nervous system is unique in that it continuously renews itself and
regenerates after injury. These properties are attributed to the presence of olfactory glia …

Clinical cell therapy guidelines for neurorestoration (IANR/CANR 2017)

H Huang, W Young, L Chen, S Feng… - Cell …, 2018 - journals.sagepub.com
Cell therapy has been shown to be a key clinical therapeutic option for central nervous
system diseases or damage. Standardization of clinical cell therapy procedures is an …

Low-dose curcumin stimulates proliferation, migration and phagocytic activity of olfactory ensheathing cells

J Tello Velasquez, ME Watts, M Todorovic, L Nazareth… - PloS one, 2014 - journals.plos.org
One of the promising strategies for neural repair therapies is the transplantation of olfactory
ensheathing cells (OECs) which are the glial cells of the olfactory system. We evaluated the …

Optimizing olfactory ensheathing cell transplantation for spinal cord injury repair

AD Gilmour, R Reshamwala, AA Wright… - Journal of …, 2020 - liebertpub.com
Cell transplantation constitutes an important avenue for development of new treatments for
spinal cord injury (SCI). These therapies are aimed at supporting neural repair and/or …