Parkinson disease (PD) is a severe neurodegenerative disorder that affects around 2% of
the population over 65 years old. It is characterized by the progressive loss of nigrostriatal …

After different types of acute central nervous system insults, including stroke, subarachnoid
haemorrhage and traumatic brain and spinal cord injuries, secondary damage plays a …

Abstract Background Rapamycin (Rapa), acarbose (ACA), and 17α-estradiol (17aE2, males
only) have health benefits that increase lifespan of mice. Little is known about how these …

Aging is associated with a decline in mitochondrial function which may contribute to age-
related diseases such as neurodegeneration, cancer, and cardiovascular diseases …

Glucagon-like peptide-1 receptor agonists (GLP1RA) have been transformative for patients
and clinicians in treating type-2 diabetes and obesity. Drugs of this class, the bioavailability …

As the number of older people has grown in recent decades, the search for new approaches
to manage or delay aging is also growing. Among the modifiable factors, diet plays a crucial …

AMP-activated protein kinase (AMPK), an important regulator of the aging process, is
expressed in various immune cells. However, its role in regulatory T cell (Treg) stability …

Abstract Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a key glycolytic enzyme
that participates in various cellular events, such as DNA repair and apoptosis. The functional …

The most common factor that contributes to aging is the loss of proteostasis, resulting in an
excess amount of non-functional/damaged proteins. These proteins lead to various age …

Aging is a natural, gradual, and inevitable process associated with a series of changes at
the molecular, cellular, and tissue levels that can lead to an increased risk of many diseases …