Abnormal tau lesions (non-argyrophilic pretangle material, argyrophilic neuropil threads,
neurofibrillary tangles) in select types of neurons are crucial for the pathogenesis of sporadic …

There is increasing interest in the early phase of Alzheimer's disease before severe
neuronal dysfunction occurs, but it is still not known when or where in the central nervous …

Two thousand three hundred and thirty two nonselected brains from 1-to 100-year-old
individuals were examined using immunocytochemistry (AT8) and Gallyas silver staining for …

Brains of 42 individuals between the ages of 4 and 29 were examined with antibodies (AT8,
4G8) and silver stains for the presence of intraneuronal and extracellular protein aggregates …

Abstract See Grinberg and Heinsen (doi: 10.1093/brain/awx261) for a scientific commentary
on this article. Clinical evidence suggests that aberrant tau accumulation in the locus …

The locus ceruleus (LC) contains norepinephrine (NE)-synthesizing neurons that send
diffuse projections throughout the CNS. The LC-NE system has a major role in arousal …

Projection neurons (not only those of the locus coeruleus) are sturdy and can survive for a
lifetime despite the existence of Alzheimer-related abnormal tau. Currently, little understood …

As indicated by its title, this monograph deals chiefly with morphologically recognizable
deviations from the normal anatomical condition of the human CNS. The AD-associated …

Vagus nerve stimulation (VNS) has become an established therapy for difficult-to-treat
epilepsy during the past 20 years. The vagus nerve provides a unique entrance to the brain …

The brainstem locus coeruleus (LC) supplies norepinephrine to the forebrain and
degenerates in Alzheimer's disease (AD). Loss of LC neurons is correlated with increased …