Recombinant and chimeric disintegrins in preclinical research

V David, BB Succar, JA De Moraes… - Toxins, 2018 - mdpi.com
Disintegrins are a family of small cysteine-rich peptides, found in a wide variety of snake
venoms of different phylogenetic origin. These peptides selectively bind to integrins, which …

Functional characterization of six aspartate (D) recombinant mojastin mutants (r-Moj): A second aspartate amino acid carboxyl to the RGD in r-Moj-D_ peptides is not …

CJ Ramos, DA Gutierrez, AS Aranda, MA Koshlaychuk… - Toxicon, 2016 - Elsevier
Disintegrins are small peptides produced in viper venom that act as integrin antagonists.
When bound to integrins, disintegrins induce altered cellular behaviors, such as apoptotic …

Inibição da integrina αvβ3 em cultura celular 3D de células tumorais e endoteliais em ambiente hipóxico utilizando a desintegrina recombinante DisBa-01

MP Baptista - 2022 - repositorio.ufscar.br
RESUMO O câncer de mama apresenta alta incidência global, sendo o tipo de câncer mais
fatal em 2020, ano no qual foram estimados 66.280 novos casos apenas no Brasil. As …

Functional analysis of four single (RGDWL, RGDWM, RGDWP, RGDMN) and two double (RGDNM, RGDMP) mutants: The importance of methionine (M) in the …

DA Gutierrez, AS Aranda, DAR Carrillo… - Toxicon, 2016 - Elsevier
We have demonstrated in previous studies that a single amino acid change can alter the
activity of the recombinant disintegrin r-Moj. In this study, four r-Moj recombinants containing …

RNA sequence analyses of r-Moj-DM treated cells: TXNIP is required to induce apoptosis of SK-Mel-28

TD McBride, U Andrew, N Ly, JG Soto - Toxicon, 2016 - Elsevier
RNA sequencing of untreated and r-Moj-DM treated SK-Mel-28 cells was performed after 6
h, to begin unraveling the apoptotic pathway induced by r-Moj-DM. Bioinformatic analyses of …

[PDF][PDF] Normal human monocytic cell line CRL9855 can be transformed into macrophages with very low concentrations of phorbol 12-myristate 13-acetate

RM Marinescu, ME Mickael, AM Enciu, LC Ceafalan - cellidentity.org
Monocytes are leukocytes that can differentiate into tissue macrophages and act in immune
surveillance and tissue reconstruction. They are frequently used in vitro to study …

Recombinant and Chimeric Disintegrins in Preclinical Research

D Victor, BB Succar, JA de Moraes… - Toxins, 2018 - search.proquest.com
Disintegrins are a family of small cysteine-rich peptides, found in a wide variety of snake
venoms of different phylogenetic origin. These peptides selectively bind to integrins, which …

Inibição do cross-talk entre alfa (v) beta (3) e VEGFR2 na angiogênese pela desintegrina DisBa-01

TM Danilucci - 2018 - repositorio.ufscar.br
Angiogênese é o processo de formação de novos vasos sanguíneos a partir de vasos
preexistentes, o qual ocorre tanto em condições fisiológicas quanto patológicas. O equilíbrio …

[引用][C] 整合素表达变化在乳腺癌发生及发展中的作用研究进展

吕凤, 郭晓静, 付丽 - 中华病理学杂志, 2015