Osteocytes are an ancient cell, appearing in fossilized skeletal remains of early fish and
dinosaurs. Despite its relative high abundance, even in the context of nonskeletal cells, the …

With the reignited push for manned spaceflight and the development of companies focused
on commercializing spaceflight, increased human ventures into space are inevitable …

Humans are spending an increasing amount of time in space, where exposure to conditions
of microgravity causes 1–2% bone loss per month in astronauts. Through data collected …

In recent decades, the field of bone mechanobiology has sought experimental techniques to
unravel the molecular mechanisms governing the phenomenon of mechanically regulated …

Experiencing real weightlessness in space is a dream for many of us who are interested in
space research. Although space traveling fascinates us, it can cause both short-term and …

Abstract Space sojourns are challenging for life. The ability of the human body to adapt to
these extreme conditions has been noted since the beginning of human space travel …

All life forms have evolved under the constant force of gravity on Earth and developed ways
to counterbalance acceleration load. In space, shear forces, buoyance-driven convection …

The skeleton is a dynamic tissue continuously adapting to mechanical stimuli. Although
matrix‐embedded osteocytes are considered as the key mechanoresponsive bone cells, all …

Motivation To curate and organize expensive spaceflight experiments conducted aboard
space stations and maximize the scientific return of investment, while democratizing access …

Disuse and aging are known risk factors associated with low bone mass and quality
deterioration, resulting in increased fracture risk. Indeed, current and emerging evidence …