Alcoholism is a chronic relapsing disorder. Major characteristics observed in alcoholics
during an initial period of alcohol abstinence are altered physiological functions and a …

The alcohol‐preferring, P, rat was developed by selective breeding to study ethanol drinking
behavior and its consequences. Characterization of this line indicates the P rat meets all of …

Background: The development of dependence may have significant motivational
consequences regarding continued use and abuse of ethanol. We have developed a mouse …

Understanding the psychological mechanisms and underlying neurobiology of relapse
behavior is essential for improving the treatment of addiction. Because the neurobiology of …

This report of the proceedings of a symposium presented at the 2004 Research Society on
Alcoholism Meeting provides evidence linking stress during sobriety to craving that …

The Indiana lines of selected rats, the HAD and LAD replicates and the P and NP lines, were
bred for high and low alcohol preference. The P and HAD lines have met criteria for an …

Rationale We previously demonstrated that chronic ethanol exposure and withdrawal
experience significantly increased subsequent voluntary ethanol intake in C57BL/6J mice …

Heavy episodic drinking early in adolescence is associated with increased risk of addiction
and other stress-related disorders later in life. This suggests that adolescent alcohol abuse …

Background: Studies in rodents have determined that intermittent exposure to alcohol vapor
can increase subsequent ethanol self‐administration, measured with operant and 2‐bottle …

Rationale The rationale for proposing the “kindling”/stress hypothesis is to provide a
conceptual basis for the insidious development and maintenance of alcohol abuse …