Increasing evidence from epidemiological, preclinical and clinical studies suggests that
dysregulated inflammatory response plays a pivotal role in a multitude of chronic ailments …

Prostaglandins and thromboxane are lipid signaling molecules deriving from arachidonic
acid by the action of the cyclooxygenase isoenzymes COX-1 and COX-2. The role of …

Considerable arguments remain regarding the diverse biological activities of
polyunsaturated fatty acids (PUFA). One of the most interesting but controversial dietary …

Basal cell carcinoma is the most common malignant neoplasm in humans and its incidence
has increased over the last decades. Its high frequency significantly burdens the health …

The cyclooxygenase-2 (COX-2) is a potent enzyme that converts arachidonic acid to
prostaglandins (PG), including PGE2, a key mediator of inflammation and angiogenesis …

Head and neck squamous cell carcinoma (HNSCC), which originates in the head or neck
tissues, is characterized by high rates of recurrence and metastasis. Inflammation is …

Prostaglandins are a class of molecules that mediate cellular inflammatory responses and
control cell growth. The oxidative conversion of arachidonic acid to prostaglandin H2 is …

O carcinoma basocelular é a neoplasia maligna mais comum em humanos e sua incidência
vem aumentando nas últimas décadas. Sua grande frequência gera significativo ônus ao …

The anti-inflammatory protein annexin A1 (ANXA1) has been associated with cancer
progression and metastasis, suggesting its role in regulating tumor cell proliferation. We …

Head and neck squamous cell carcinoma (HNSCC) originates from the squamous
epithelium of the oral cavity, oropharynx, larynx, and hypopharynx. HNSCC in the oral cavity …