The Hippo pathway was originally identified and named through screening for mutations in
Drosophila, and the core components of the Hippo pathway are highly conserved in …

Despite colorectal cancer remaining a leading worldwide cause of cancer-related death,
there remains a paucity of effective treatments for advanced disease. The molecular …

Sepsis‐induced muscle atrophy often increases morbidity and mortality in intensive care unit
(ICU) patients, yet neither therapeutic target nor optimal animal model is available for this …

A single nucleotide substitution in the third intron of insulin-like growth factor 2 (IGF2) is
associated with increased muscle mass and reduced subcutaneous fat in domestic pigs …

ZC3H11A (zinc finger CCCH domain–containing protein 11A) is a stress-induced mRNA-
binding protein required for efficient growth of nuclear-replicating viruses. The cellular …

ZBED6 (zinc finger BED domain containing protein 6) is a transcription factor unique to
placental mammals and its interaction with the IGF2 (insulin-like growth factor 2) locus plays …

Quantum dots (QDs), including CdSe/ZnS, are nanoparticles emitting various wavelengths
of fluorescent light depending on their size. Fluorescence allows them to be exploited for in …

Maintenance of genomic diversity is critically dependent on gene regulation at the
transcriptional level. This occurs via the interaction of regulatory DNA sequence motifs with …

Background Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths
worldwide. Recent studies have observed causative mutations in susceptible genes related …

Domestic animals are unique models for biomedical research due to their long history
(thousands of years) of strong phenotypic selection. This process has enriched for novel …